This study investigated, using digital bitewing radiography, the progression and regression of approximal caries in adolescent subjects chewing a sugar-free gum containing 54 mg CPP-ACP relative to the identical gum without CPP-ACP. 2,720 subjects from 29 schools were randomly assigned to one of the two gums and were instructed to chew their assigned gum for 3 × 10 min/day, with one session supervised on school days, over the 24-month study period. Standardized digital bitewing radiographs were taken at the baseline and 24-month clinical examinations for each subject. The radiographs, scored by a single examiner, were assessed for approximal surface dental caries at both the enamel and dentine level. Surface level transitions were scored using a transition matrix. Caries progression or regression was analysed using proportional-odds ordered logistic regression modelling of the transition scores at the tooth surface level. There was a statistically significant difference in the frequency distributions of the transition scores between the two gum groups (OR = 0.82, p = 0.03). For subjects chewing the CPP-ACP gum the odds of a surface experiencing caries progression were 18% less than those of a surface experiencing caries progression for subjects chewing the control gum. In conclusion, the 54 mg CPP-ACP sugar-free gum significantly slowed progression and enhanced regression of approximal caries relative to a control sugar-free gum in a 24-month clinical trial.
© 2008 S. Karger AG, Basel
- Approximal caries progression
- Casein phosphopeptide-amorphous calcium phosphate nanocomplexes
- Digital bitewing radiography
- Enamel remineralization
- Ordinal categorical data
- Randomized clinical trial
- Sugar-free chewing gum
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Eric C. Reynolds
School of Dental Science, University of Melbourne
720 Swanston Street
Parkville, Vic. 3010 (Australia)
Tel. +61 3 9341 1547, Fax +61 3 9341 1597, E-Mail firstname.lastname@example.org
Received: March 14, 2007
Accepted after revision: February 14, 2008
Published online: April 29, 2008
Number of Print Pages : 14
Number of Figures : 1, Number of Tables : 10, Number of References : 64
Vol. 42, No. 3, Year 2008 (Cover Date: May 2008)
Journal Editor: Shellis R.P. (Bristol)
ISSN: 0008–6568 (Print), eISSN: 1421–976X (Online)
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