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Vol. 52, No. 4, 2008
Issue release date: September 2008
Ann Nutr Metab 2008;52:281–287

Relative Bioavailability of Two Forms of a Novel Water-Soluble Coenzyme Q10

Žmitek J. · Šmidovnik A. · Fir M. · Prošek M. · Žmitek K. · Walczak J. · Pravst I.
aNational Institute of Chemistry, bHigher School of Applied Sciences, cJožef Stefan Institute, dFaculty of Chemistry and Chemical Technology, University of Ljubljana, and eValens Int., Ljubljana, Slovenia; fBIOFANA Spółka z o.o., Kutno, Poland

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Background: Coenzyme Q10 (CoQ10) is a naturally occurring compound that plays a fundamental role in cellular bioenergetics and is an effective antioxidant. Numerous health benefits of CoQ10 supplementation have been reported, resulting in growing demands for its use in fortifying food. Due to its insolubility in water, the enrichment of most food products is not easily achievable and its in vivo bioavailability is known to be poor. Water solubility was increased significantly with the use of an inclusion complex with β-cyclodextrin. This complex is widely used as Q10Vital® in the food industry, while its in vivo absorption in humans has not previously been studied. Methods: A randomized three-period crossover clinical trial was therefore performed in which a single dose of CoQ10 was administered orally to healthy human subjects. The pharmacokinetic parameters of two forms of the novel CoQ10 material were determined and compared to soft-gel capsules with CoQ10 in soybean oil that acted as a reference. Results: The mean increase of CoQ10 plasma concentrations after dosing with Q10Vital® forms was determined to be over the reference formulation and the area under the curve values, extrapolated to infinity (AUCinf), were also higher with the tested forms; statistically significant 120 and 79% increases over the reference were calculated for the Q10Vital® liquid and powder, respectively. Conclusions: The study revealed that the absorption and bioavailability of CoQ10 in the novel formulations are significantly increased, probably due to the enhanced water solubility.

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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  1. Crane FL: Biochemical functions of coenzyme Q10. J Am Coll Nutr 2001;20:591–598.
  2. Nohl H, Kozlov AV, Staniek K, Gille L: The multiple functions of coenzyme Q. Bioorg Chem 2001;29:1–13.
  3. Mellors A, Tappel AL: The inhibition of mitochondrial peroxidation by ubiquinone and ubiquinol. J Biol Chem 1966;241:4353–4356.
  4. Bribiva K, Sies H: Nonenzymatic antioxidant defense systems; in Frei B (ed): Natural Antioxidants in Human Health and Disease. San Diego, Academic Press, 1994, pp 107–128.
  5. Ishii N, Senoo-Matsuda N, Miyake K, Yasuda K, Ishii T, Hartman PS, et al: Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress. Mech Ageing Dev 2004;125:41–46.
  6. Frei B, Kim MC, Ames BN: Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc Natl Acad Sci USA 1990;87:4879–4883.
  7. Yamamoto Y: Coenzyme Q10 as a front-line antioxidant against oxidative stress. J Clin Biochem Nutr 2005;36:29–35.
  8. Sastry PS, Jayaraman J, Ramasarma T: Distribution of coenzyme Q in rat liver cell fractions. Nature 1961;189:577.
  9. Ely JTA, Krone CA: A brief update on ubiquinone (coenzyme Q10). J Orthomol Med 2000;15:63–68.
  10. Littarru GP, Tiano L: Clinical aspects of coenzyme Q10: an update. Curr Opin Clin Nutr Metab Care 2005;8:641–646.
  11. Dhanasekaran M, Ren J: The emerging role of coenzyme Q10 in aging, neurodegeneration, cardiovascular disease, cancer and diabetes mellitus. Curr Neurovasc Res 2005;2:447–459.
  12. Borek C: Biochemical and medical applications of coenzyme Q10. Agro Food Ind Hi Tec 2006;17:24–26.

    External Resources

  13. Belardinelli R, Mucaj A, Lacalaprice F, Solenghi M, Seddaiu G, Principi F, et al: Coenzyme Q10 and exercise training in chronic heart failure. Eur Heart J 2006;27:2675–2681.
  14. Langsjoen PH, Langsjoen A, Willis R, Folkers K: Treatment of hypertrophic cardiomyopathy with coenzyme Q10. Mol Aspects Med 1997;18:S145–S151.
  15. Tran MT, Mitchell TM, Kennedy DT, Giles JT: Role of coenzyme Q10 in chronic heart failure, angina, and hypertension. Pharmacotherapy 2001;21:797–806.
  16. Cooper JM, Schapira AHV: Friedreich’s ataxia: coenzyme Q10 and vitamin E therapy. Mitochondrion 2007;7:S127–S135.
  17. Musumeci O, Naini A, Slonim AE, Skavin N, Hadjigeorgiou GL, Krawiecki N, et al: Familial cerebellar ataxia with muscle coenzyme Q10 deficiency. Neurology 2001;56:849–855.
  18. Artuch R, Brea-Calvo G, Briones P, Aracil A, Galvan M, Espinos C, et al: Cerebellar ataxia with coenzyme Q10 deficiency: diagnosis and follow-up after coenzyme Q10 supplementation. J Neurol Sci 2006;246:153–158.
  19. Chew GT, Watts GF: Coenzyme Q10 and diabetic endotheliopathy: oxidative stress and the ‘recoupling hypothesis’. QJM 2004;97:537–548.
  20. Balercia G, Mosca F, Mantero F, Boscaro M, Mancini A, Ricciardo-Lamonica G, et al: Coenzyme Q10 supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril 2004;81:93–98.
  21. Hill GJ, Shriver BJ, Arnett DB: Examining intentions to use CoQ10 amongst breast cancer patients. Am J Health Behav 2006;30:313–321.
  22. Portakal O, Ozkaya O, Inal ME, Bozan B, Kosan M, Sayek I: Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem 2000;33:279–284.
  23. Lockwood K, Moesgaard S, Folkers K: Partial and complete regression of breast-cancer in patients in relation to dosage of coenzyme Q10. Biochem Biophys Res Commun 1994;199:1504–1508.
  24. Roffe L, Schmidt K, Ernst E: Efficacy of coenzyme Q10 for improved tolerability of cancer treatments: a systematic review. J Clin Oncol 2004;22:4418–4424.
  25. Yuvaraj S, Premkumar VG, Vijayasarathy K, Gangadaran SGD, Sachdanandam P: Ameliorating effect of coenzyme Q10, riboflavin and niacin in tamoxifen-treated postmenopausal breast cancer patients with special reference to lipids and lipoproteins. Clin Biochem 2007;40:623–628.
  26. Blatt T, Mundt C, Mummert C, Maksiuk T, Wolber R, Keyhani R, et al: Modulation of oxidative stress in human skin of old donors. Z Gerontol Geriatr 1999;32:83–88.
  27. Caso G, Kelly P, McNurlan MA, Lawson WE: Effect of coenzyme Q10 on myopathic symptoms in patients treated with statins. Am J Cardiol 2007;99:1409–1412.
  28. Bliznakov EG: Lipid-lowering drugs (statins), cholesterol, and coenzyme Q10. The Baycol case – a modern Pandora’s box. Biomed Pharmacother 2002;56:56–59.
  29. Mattila P, Kumpulainen J: Coenzymes Q9 and Q10: contents in foods and dietary intake. J Food Compos Anal 2001;14:409–417.
  30. Strazisar M, Fir M, Golc-Wondra A, Milivojevic L, Prosek M, Abram V: Quantitative determination of coenyzme Q10 by liquid chromatography and liquid chromatography/mass spectrometry in dairy products. J AOAC Int 2005;88:1020–1027.
  31. Weber C, Bysted A, Holmer G: Coenzyme Q10 in the diet – daily intake and relative bioavailability. Mol Aspects Med 1997;18:S251–S254.
  32. Ashwell M: Concepts of Functional Foods. Brussels, International Life Sciences Institute, 2002.
  33. Madsen C: Functional foods in Europe. Ann Nutr Metab 2007;51:298–299.
  34. Prosek M, Smidovnik A, Fir M, Strazisar M, Golc Wondra A, Andrensek S, Zmitek J: Water-soluble coenzyme Q10 inclusion complex with β-cyclodextrin, process of preparing, and use thereof. Pat. SI 21783, Pat. Appl. PCT/SI2005/000013 (WO 2005/111224 A2, 2005).
  35. Uekama K, Hirayama F, Irie T: Cyclodextrin drug carrier systems. Chem Rev 1998;98:2045–2076.
  36. Prosek M, Smidovnik A, Fir M, Golc-Wondra A, Zmitek J, Kostanjevec B, Donsa B, Vindis-Zelenko B: Use of coenzyme Q10 for improved effectiveness of animal husbandry and production of animal tissues with an increased content of the said coenzyme. Pat. Appl. PCT/SI2007/000040.
  37. Bhagavan HN, Chopra RK: Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion 2007;7:S78–S88.
  38. Kaikkonen J, Tuomainen TP, Nyyssonen K, Salonen JT: Coenzyme Q10: absorption, antioxidative properties, determinants, and plasma levels. Free Radic Res 2002;36:389–397.
  39. Chopra RK, Goldman R, Sinatra ST, Bhagavan HN: Relative bioavailability of coenzyme Q10 formulations in human subjects. Int J Vitam Nutr Res 1998;68:109–113.
  40. Kurowska EM, Dresser G, Deutsch L, Bassoo E, Freeman DJ: Relative bioavailability and antioxidant potential of two coenzyme Q10 preparations. Ann Nutr Metab 2003;47:16–21.
  41. Schulz C, Obermuller-Jevic UC, Hasselwander O, Bernhardt J, Biesalski HK: Comparison of the relative bioavailability of different coenzyme Q10 formulations with a novel solubilizate (Solu Q10). Int J Food Sci Nutr 2006;57:546–555.
  42. Weis M, Mortensen SA, Rassing MR, MollerSonnergaard J, Poulsen G, Rasmussen SN: Bioavailability of four oral coenzyme Q10 formulations in healthy volunteers. Mol Aspects Med 1994;15:S273–S280.
  43. Miles MV, Horn P, Miles L, Tang P, Steele P, DeGrauw T: Bioequivalence of coenzyme Q10 from over-the-counter supplements. Nutr Res 2002;22:919–929.
  44. Joshi SS, Sawant SV, Shedge A, Halpner AD: Comparative bioavailability of two novel coenzyme Q10 preparations in humans. Int J Clin Pharmacol Ther 2003;41:42–48.
  45. Terao K, Nakata D, Fukumi H, Schmid G, Arima H, Hirayama F, et al: Enhancement of oral bioavailability of coenzyme Q10 by complexation with γ-cyclodextrin in healthy adults. Nutr Res 2006;26:503–508.
  46. Kaplan P, Sebestianova N, Turiakova J, Kucera I: Determination of coenzyme Q in human plasma. Physiol Res 1996;45:39–45.
  47. Kaikkonen J, Nyyssonen K, Porkkala-Sarataho E, Poulsen HE, Metsa-Ketela T, Hayn M, et al: Effect of oral coenzyme Q10 supplementation on the oxidation resistance of human VLDL+LDL fraction: absorption and antioxidative properties of oil and granule-based preparations. Free Radic Biol Med 1997;22:1195–1202.

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