Journal Mobile Options
Table of Contents
Vol. 54, No. 5, 2008
Issue release date: October 2008
Section title: Behavioural Science Section
Free Access
Gerontology 2008;54:292–299

Effect of Micronutrient Supplementation on Mood in Nursing Home Residents

Gosney M.A.a · Hammond M.F.b · Shenkin A.c · Allsup S.d
aInstitute of Health Sciences, University of Reading, Reading, bDivision of Clinical Psychology, University of Liverpool, cDepartment of Clinical Chemistry, Royal Liverpool University Hospital, Liverpool, dWhiston Hospital, Prescot, UK
email Corresponding Author

Prof. Margot Gosney

University of Reading, Institute of Health Sciences

London Road, Building 22, 1st Floor

Reading RG1 5AQ (UK)

Tel. +44 118 378 6853, Fax +44 118 378 6862, E-Mail m.a.gosney@reading.


  1. Phillips CJ, Henderson AS: The prevalence of depression among Australian nursing home residents: results using draft ICD-10 and DSM-III-R criteria. Psychol Med 1991;21:739–748.
  2. Burrows AB, Satlin A, Salzman C, Nobel K, Lipsitz LA: Depression in a long-term care facility: clinical features and discordance between nursing assessment and patient interviews. J Am Geriatr Soc 1995;43:1118–1122.
  3. Mann AH, Schneider J, Mozley CG, Levin E, Blizard R, Netten A, Kharicha K, Egelstaff R, Abbey A, Todd C: Depression and the response of residential homes to physical health needs. Int J Geriatr Psychiatry 2000;15:1105–1112.
  4. Teresi J, Abrams R, Holmes D, Ramirez M, Eimicke J: Prevalence of depression and depression recognition in nursing homes. Soc Psychiatry Psychiatr Epidemiol 2001;36:613–620.
  5. Beekman AT, Copeland JR, Prince MJ: Review of community prevalence of depression in later life. Br J Psychiatry 1999;174:307–311.
  6. Djernes JK: Prevalence and predictors of depression in populations of elderly: a review. Acta Psychiatr Scand 2006;113:372–387.
  7. Watson LC, Lehmann S, Mayer L, Samus Q, Baker A, Brandt J, Steele C, Rabins P, Rosenblatt A, Lyketsos C: Depression in assisted living is common and related to physical burden. Am J Geriatr Psychiatry 2006;14:876–883.
  8. Beekman AT, Kriegsman DM, Deeg DJ, van Tilburg W: The association of physical health and depressive symptoms in the older population: age and sex differences. Soc Psychiatry Psychiatr Epidemiol 1995:30:32–38.
  9. Geerlings SW, Beekman AT, Deeg DJ, Van Tilburg W: Physical health and the onset and persistence of depression in older adults: an eight-wave prospective community-based study. Psychol Med 2000;30:369–380.
  10. Watson LC, Garrett JM, Sloane PD, Gruber-Baldini AL, Zimmerman S: Depression in assisted living: results from a four-state study. Am J Geriatr Psychiatry 2003;11:534–542.
  11. Mandal SK, Ray AK: Vitamin C status of elderly patients on admission into an assessment geriatric ward. J Int Med Res 1987;15:96–98.
  12. Girodon F, Lombard M, Galan P, Brunet-Lecomte P, Monget AL, Arnaud J, Preziosi P, Hercberg S: Effect of micronutrient supplementation on infection in institutionalized elderly subjects: a controlled trial. Ann Nutr Metab 1997;41:98–107.
  13. Bates CJ, Prentice A, Cole TJ, van der Pols JC, Doyle W, Finch S, Smithers G, Clarke PC: Micronutrients: highlights and research challenges from the 1994–1995 National Diet and Nutrition Survey of people aged 65 years and over. Br J Nutr 1999;82:7–15.
  14. Bates CJ, Prentice A, Finch S: Gender differences in food and nutrient intakes and status indices from the National Diet and Nutrition Survey of people aged 65 years and over. Eur J Clin Nutr 1999;53:694–699.
  15. van der Wielen RP, van Heereveld HA, de Groot CP, van Staveren WA: Nutritional status of elderly female nursing home residents; the effect of supplementation with a physiological dose of water-soluble vitamins. Eur J Clin Nutr 1995;49:665–674.
  16. Wouters-Wesseling W, Wouters AE, Kleijer CN, Bindels JG, de Groot CP, van Staveren WA: Study of the effect of a liquid nutrition supplement on the nutritional status of psycho-geriatric nursing home patients. Eur J Clin Nutr 2002;56:245–251.
  17. Ussher JM, Swann C: A double blind placebo controlled trial examining the relationship between Health-Related Quality of Life and dietary supplements. Br J Health Psychol 2000;5:173–187.
  18. Benton D, Donohoe RT: The effects of nutrients on mood. Public Health Nutr 1999;2:403–409.
  19. Benton D: Carbohydrate ingestion, blood glucose and mood. Neurosci Biobehav Rev 2002;26:293–308.
  20. Benton D, Nabb S: Carbohydrate, memory, and mood. Nutr Rev 2003;61:S61–S67.
  21. Carroll D, Ring C, Suter M, Willemsen G: The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial. Psychopharmacology (Berl) 2000;150:220–225.
  22. Coppen A, Bailey J: Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial. J Affect Disord 2000;60:121–130.
  23. Smith A, Clark R, Nutt D, Haller J, Hayward S, Perry K: Anti-oxidant vitamins and mental performance of the elderly. Hum Psychopharmacol 1999;14:459–471.
  24. Rayman MP: The importance of selenium to human health. Lancet 2000;356:233–241.
  25. Rayman MP, Rayman MP: The argument for increasing selenium intake. Proc Nutr Soc 2002;61:203–215.
  26. Brown KM, Arthur JR: Selenium, selenoproteins and human health: a review. Public Health Nutr 2001;4:593–599.
  27. Sher L: Role of thyroid hormones in the effects of selenium on mood, behavior, and cognitive function. Med Hypotheses 2001;57:480–483.
  28. Girre C, Hispard E, Therond P, Guedj S, Bourdon R, Dally S: Effect of abstinence from alcohol on the depression of glutathione peroxidase activity and selenium and vitamin E levels in chronic alcoholic patients. Alcohol Clin Exp Res 1990;14:909–912.
  29. Sher L: Role of selenium depletion in the etiopathogenesis of depression in patients with alcoholism. Med Hypotheses 2002;59:330–333.
  30. Bodnar LM, Wisner KL: Nutrition and depression: implications for improving mental health among childbearing-aged women. Biol Psychiatry 2005;58:679–685.
  31. Paku S, Inaba Y, Seki C, Hara Y, Yamazaki M, Tsukada M: Selenium deficiency and electrocardiography changes in patients with severe motor and intellectual disabilities on long[-]term tube feeding (in Japanese). No To Hattatsu 2002;34:37–42.
    External Resources
  32. Vaddadi KS, Soosai E, Vaddadi G: Low blood selenium concentrations in schizophrenic patients on clozapine. Br J Clin Pharmacol 2003;55:307–309.
  33. Smorgon C, Mari E, Atti AR, Dalla Nora E, Zamboni PF, Calzoni F, Passaro A, Fellin R: Trace elements and cognitive impairment: an elderly cohort study. Arch Gerontol Geriatr Suppl 2004;(9):393–402.
  34. Akbaraly NT, Hininger-Favier I, Carriere I, Arnaud J, Gourlet V, Roussel AM, Berr C: Plasma selenium over time and cognitive decline in the elderly. Epidemiology 2007;18:52–58.
  35. Gao S, Jin Y, Hall KS, Liang C, Unverzagt FW, Ji R, Murrell JR, Cao J, Shen J, Ma F, Matesan J, Ying B, Cheng Y, Bian J, Li P, Hendrie HC: Selenium level and cognitive function in rural elderly Chinese. Am J Epidemiol 2007;165:955–965.
  36. Hawkes WC, Hornboste L: Effects of dietary selenium on mood in healthy men living in a metabolic research unit. Biol Psychiatry 1996;39:121–128.
  37. Rayman M, Thompson A, Warren-Perry M, Galassini R, Catterick J, Hall E, Lawrence D, Bliss J: Impact of selenium on mood and quality of life: a randomized, controlled trial. Biol Psychiatry 2006;59:147–154.
  38. Benton D, Cook R: Selenium supplementation improves mood in a double-blind crossover trial. Psychopharmacology (Berl) 1990;102:549–550.
  39. Benton D, Cook R: The impact of selenium supplementation on mood. Biol Psychiatry 1991;29:1092–1098.
  40. Shor-Posner G, Lecusay R, Miguez MJ, Moreno-Black G, Zhang G, Rodriguez N, Burbano X, Baum M, Wilkie F: Psychological burden in the era of HAART: impact of selenium therapy. Int J Psychiatry Med 2003;33:55–69.
  41. Yohannes AM, Baldwin RC, Connolly MJ: Depression and anxiety in elderly outpatients with chronic obstructive pulmonary disease: prevalence, and validation of the BASDEC screening questionnaire. Int J Geriatr Psychiatry 2000;15:1090–1096.
  42. MAFF: Food Surveillance Information Sheet No 126. London, Joint Food Safety and Standards Information Group, UK Ministry of Agriculture, Fisheries and Food, 1997.
  43. Bates CJ, Thane CW, Prentice A, Delves HT: Selenium status and its correlates in a British national diet and nutrition survey: people aged 65 years and over. J Trace Elem Med Biol 2002;16:1–8.
  44. Olivieri O, Girelli D, Azzini M, Stanzial AM, Russo C, Ferroni M, Corrocher R: Low selenium status in the elderly influences thyroid hormones. Clin Sci (Lond) 1995;89:637–642.
  45. Sher L: Selenium and human health. Lancet 2000;356:943.
  46. Lawton MP, Parmelee PA, Katz IR, Nesselroade J: Affective states in normal and depressed older people. J Gerontol B Psychol Sci Soc Sci 1996;51:309–316.
  47. Benton D, Griffiths R, Haller J: Thiamine supplementation mood and cognitive functioning. Psychopharmacology (Berl) 1997;129:66–71.
  48. Smidt LJ, Cremin FM, Grivetti LE, Clifford AJ: Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency. J Gerontol 1991;46:16–22.