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Vol. 48, No. 2, 1988
Issue release date: 1988
Cytogenet Cell Genet 1988;48:107–111

Genetic mapping of the human polymeric immunoglobulin receptor gene to chromosome region 1q31→q41

Davidson M.K. · Le Beau M.M. · Eddy R.L. · Shows T.B. · DiPietro L.A. · Kingzette M. · Hanly W.C.
aDepartment of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL, bJoint Section of Hematology/Oncology, University of Chicago, Chicago, IL, and cDepartment of Human Genetics, Roswell Park Memorial Institute, Buffalo, NY

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Polymeric immunoglobulin receptor (PIGR) is a transmembrane glycoprotein which is expressed by epithelial cells and is involved in the transcellular transport of polymeric immunoglobulins into secretions. We cloned the human gene for PIGR and used the clone to obtain probes to determine the chromosomal localization of PIGR. Analysis of somatic cell hybrids and in situ chromosomal hybridization localized the human PIGR gene locus to 1q31→q41.

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