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Table of Contents
Vol. 57, No. 4, 1991
Issue release date: 1991
Section title: Gene Mapping, Cloning, and Sequencing
Cytogenet Cell Genet 1991;57:187–192
(DOI:10.1159/000133143)

Chromosomal localization of the human gene for annexin V (placental anticoagulant protein I) to 4q26→q28

Tait J.F. · Frankenberry D.A. · Shiang R. · Murray J.C. · Adler D.A. · Disteche C.M.
Departments of aLaboratory Medicine and bPathology, University of Washington, Seattle, WA, and cDepartment of Pediatrics, University of Iowa, Iowa City, IA (USA)

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Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning, and Sequencing

Accepted: 2/22/1991
Published online: 5/14/2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Annexin V is a member of a new family of calcium-dependent phospholipid-binding proteins. It has been previously isolated as placental anticoagulant protein I, inhibitor of blood coagulation, vascular anticoagulant-α, endonexin II, lipocortin V, placental protein 4, and anchorin CΠ. The human gene encoding annexin V (ANX5) was localized to 4q26→q28 by in situ hybridization with a cDNA probe and polymerase chain-reaction (PCR) analysis of a human × hamster hybrid cell panel. The regional localization to 4q26→q28 was supported by Southern-blot analysis of a human cell line with a deletion in 4q23→q27. This localization overlaps but differs slightly from the previous assignment of ANX5 to 4q28→q32. Digestion with Pvull and Taql identified polymorphisms at the ANX5 locus; the Pvull polymorphism could also be detected by PCR analysis.


Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning, and Sequencing

Accepted: 2/22/1991
Published online: 5/14/2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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