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Vol. 66, No. 2, 1994
Issue release date: 1994
Cytogenet Cell Genet 1994;66:104–106

The gene encoding myeloid α-3-fucosyltransferase (FUT4) is located between D11S388 and D11S919 on 11q21

Reguigne I. · James M.R. · Richard III C.W. · Mollicone R. · Seawright A. · Lowe J.B. · Oriol R. · Couillin P.
aNSERM U178, Villejuif Cedex (France); bINSERM U358 and CEPH, Paris (France); cDepartments of Psychiatry and Human Genetics, University of Pittsburgh, Pittsburgh PA (USA); dMRC Human Genetics Unit, Western General Hospital, Edinburgh (UK); and eHoward Hughes Medical Institute, Ann Arbor MI (USA)

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The last step in the biosynthesis of Lex antigen, the addition of a fucose to precursor polysaccharides, can be catalyzed by different α-3-fucosyltransferases. We localized the gene (FUT4) encoding myeloid α-3-fucosyltransferase by PCR assay using panels of somatic cell and radiation hybrids which retain different rearrangements of chromosome 11. FUT4 was assigned to chromosome band 11q21 between D11S388 and D11S919.

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