Human gp130 transducer chain gene (IL6ST) is localized to chromosome band 5q11 and possesses a pseudogene on chromosome band 17p11Rodriguez C. · Grosgeorge J. · Nguyen V.C. · Gaudray P. · Theillet C.
aInstitut de Génétique Moléculaire de Montpellier, CNRS UMR 9942, Montpellier; baboratoire de Génétique Moléculaire des Cancers Humains, CNRS URA 1462, UFR de Médecine, Nice; and caboratoire de Cytogénétique et Génétique Oncologiques, CNRS URA 1158, Institut Gustave Roussy, Villejuif (France)
Human gp130 (IL6ST) is one of the most widely used chains of the cytokine receptor family. Indeed, it is involved in signal transduction of interleukin-6, interleukin-11 leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. In a previous report, IL6ST was assigned to chromosomes 5 and 17. Here we specify the chromosomal sub-localization of IL6ST and show that the sequence detected on 17p11 corresponds, in fact, to a nontranscribed pseudogene, whereas the active gene is located at chromosome band 5q11.
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