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Vol. 70, No. 1-2, 1995
Issue release date: 1995
Cytogenet Cell Genet 1995;70:64–67
(DOI:10.1159/000133993)

Human gp130 transducer chain gene (IL6ST) is localized to chromosome band 5q11 and possesses a pseudogene on chromosome band 17p11

Rodriguez C. · Grosgeorge J. · Nguyen V.C. · Gaudray P. · Theillet C.
aInstitut de Génétique Moléculaire de Montpellier, CNRS UMR 9942, Montpellier; baboratoire de Génétique Moléculaire des Cancers Humains, CNRS URA 1462, UFR de Médecine, Nice; and caboratoire de Cytogénétique et Génétique Oncologiques, CNRS URA 1158, Institut Gustave Roussy, Villejuif (France)

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Abstract

Human gp130 (IL6ST) is one of the most widely used chains of the cytokine receptor family. Indeed, it is involved in signal transduction of interleukin-6, interleukin-11 leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. In a previous report, IL6ST was assigned to chromosomes 5 and 17. Here we specify the chromosomal sub-localization of IL6ST and show that the sequence detected on 17p11 corresponds, in fact, to a nontranscribed pseudogene, whereas the active gene is located at chromosome band 5q11.



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