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Vol. 70, No. 3-4, 1995
Issue release date: 1995
Cytogenet Cell Genet 1995;70:263–267
(DOI:10.1159/000134048)

Chromosomal localization of a gene, GFI1 encoding a novel zinc finger protein reveals a new syntenic region between man and rodents

Bell D.W. · Taguchi T. · Jenkins N.A. · Gilbert D.J. · Copeland N.G. · Gilks C.B. · Zweidler-McKay P. · Grimes H.L. · Tsichlis P.N. · Testa J.R.
aDepartment of Medical Oncology, Fox Chase Cancer Center, Philadelphia PA (USA); bMammalian Genetics Laboratory, ABL·Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick MD (USA); cDepartment of Pathology, University of British Columbia, Vancouver, British Columbia (Canada)

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Abstract

The Gfi1 gene encodes a zinc finger protein which binds DNA and is involved in transcriptional regulation. Gfi1 was assigned to the central portion of mouse Chr 5 by interspecific backcross mapping and to human chromosome band 1p22 and rat chromosome band 14p22 by fluorescence in situ hybridization (FISH). Comparative mapping data presented here describes a new syntenic region between man and rodents.



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