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Vol. 77, No. 3-4, 1997
Issue release date: 1997
Cytogenet Cell Genet 1997;77:285–287

Assignment of the canalicular multispecific organic anion transporter gene (CMOAT) to human chromosome 10q24 and mouse chromosome 19D2 by fluorescent in situ hybridization

van Kuijck M.A. · Kool M. · Merkx G.F.M. · Geurts van Kessel A. · Bindels R.J.M. · Deen P.M.T. · van Os C.H.
Departments of aCell Physiology and bHuman Genetics, University of Nijmegen, Nijmegen; cDivision of Molecular Biology, The Netherlands Cancer Institute, Amsterdam (The Netherlands)

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Rabbit epithelial basolateral chloride conductance regulator (EBCR) and rat canalicular multispecific organic anion transporter (Cmoat) are found to be homologues based on protein sequence comparison and Northern blot analysis. EBCRis, therefore, renamed as rabbit Cmoat. The gene encoding CMOAT, a transporter possibly involved in Dubin-Johnson syndrome in humans, is mapped on human chromosome 10q24 and mouse chromosome 19D2.

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