Andreas Vesalius and Jan Baptist Van Helmont are the two major personalities who contributed substantially and in a different way to the early development of renal anatomy/physiology of the 16th/17th century in the Southern Low Countries. The importance of A. Vesalius’ publication ‘de humani corporis fabrica libri septem’ cannot be overestimated. The kidney was an intriguing organ to Vesalius, the function of which he could not fully grasp. J.B. Van Helmont was the first to demonstrate the importance of the measurement of the specific gravity of the urine and relating it to physiological and pathophysiological conditions. He made accurate clinical observations supported by autopsy examinations concerning the role of the kidney in the generation of dropsy.
- Van Helmont
- Urine analysis
- Gottschalk CW: A history of renal physiology to 1950. The Kidney: Physiology and Pathophysiology (2nd edition); in Seldin DW, Giebisch G (eds). New York, Raven Press, 1992, pp 1–29.
- Andreas Vesalii Bruxellensis, scholae medicorum Patavinae professoris, de Humani corporis fabrica Libri septem. Basilea, ex officina Joannis Oporoni. Anno salutis reparatae 1543. Mense Junio.
- Roth M: Andreas Vesalius Bruxellensis. Berlin, Reimer, 1892.
- Pagel W: Jan Baptista Van Helmont. Reformer of Science and Medicine. Cambridge, Cambridge University Press, 1982.
- Van Helmont JB: Ortus Medicinae, Ignotus Hydrops, p 509, Amsterdam, 1648.
- Van Helmont JB: Ortus Medicinae, Ignotus Hydrops, p 513, Amsterdam, 1648.
- Van Helmont JB: Ortus Medicinae, Ignotus Hydrops, p 514, Amsterdam, 1648.
- Fine LG, English JA: John Blackall (1771–1860). Failure to see the obvious in dropical patients with coaguable urine? Am J Nephrol 1994;14:371–376.
Marc E. De Broe, MD, PhD
Department of Nephrology-Hypertension
University Hospital of Antwerp, Wilrijkstraat 10
B–2650 Edegem/Antwerpen (Belgium)
Tel. +32 3 821 3421, Fax +32 3 829 0100
Number of Print Pages : 8
Number of Figures : 10, Number of Tables : 0, Number of References : 8
American Journal of Nephrology
Vol. 19, No. 2, Year 1999 (Cover Date: March-April 1999)
Journal Editor: Shaul G. Massry, Los Angeles, California
ISSN: 0250–8095 (print), 1421–9670 (Online)
For additional information: http://www.karger.com/journals/ajn
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