The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26Koehler M.R. · Wissinger B. · Gorboulev V. · Koepsell H. · Schmid M.
aDepartment of Human Genetics, University of Würzburg, Biozentrum, Würzburg; bMolecular Genetics Laboratory, University Eye Hospital Tübingen, Tübingen; cDepartment of Anatomy, University of Würzburg, Würzburg (Germany)
Polyspecific transporters for organic cations (OCT) belong to a new protein family which also include organic anion transporters. The first human transporters from this family (OCT1, OCT2) have been recently cloned. They translocate small cations like tetraethylammonium, choline and monoamine neurotransmitters and are involved in hepatic and renal cation excretion, respectively. We have localized the OCT1 and OCT2 genes (SLC22A1, SLC22A2) on chromosome 6q26.
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