Neuropathology of Cyanate Toxicity in Rhesus Monkeys
Preliminary reportShaw C.-M. · Papayannopoulou T. · Stamatoyannopoulos G.
Departments of Pathology (Neuropathology) and Medicine (Hematology and Genetics), University of Washington Medical School, Seattle, Wash.
Clinical and neuropathological findings in 2 rhesus monkeys receiving intramuscular injections of sodium cyanate 40 mg/kg/day (5 days/week) are presented. The monkeys after 6 weeks of cyanate injections developed a spastic quadriplegia, showing no signs of recovery inspite of discontinuation of cyanate injections. Multifocal, relatively subtle microscopic abnormalities were found in both central and peripheral nervous systems. They were demyelination, capillary proliferation, glial proliferations and PAS-positive granules accumulating in the cytoplasm and processes of glial cells in the basal ganglia and colliculi, central chromatolysis of large neurons in the spinal cord, basal ganglia and cerebral cortex, and widespread myelin ‘digestion chambers’ in the peripheral nerves. This study suggests that the monkey is a proper experimental animal for the investigation of the problems of neurotoxicity raised by the use of cyanate in the treatment of patients with sickle cell anemia.
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