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Vol. 13, No. 6, 1975
Issue release date: 1975
Pharmacology 1975;13:502–512
(DOI:10.1159/000136944)

Effects of Δ9-Tetrahydrocannabinol and Cannabinol in Man

Karniol I.G. · Shirakawa I. · Takahashi R.N. · Knobel E. · Musty R.E.
Departments of Psychobiology, Psychiatry, and Medicine, Escola Paulista de Medicina, São Paulo

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Abstract

The interaction of Δ9-tetrahydrocannabinol (Δ9-THC) and cannabinol (CBN) was studied in man. Five male volunteers were given placebo, 50 mg CBN, 25 mg Δ9-THC, 12.5 mg Δ9-THC + 25 mg CBN, and 25 mg Δ9-THC + 50 mg CBN (orally). Administrations were spaced 1 week apart. With physiological measures, Δ9-THC produced an increase in heart rate while CBN did not. When combined, no change of the Δ9-THC effect occurred. No changes occurred on the electrocardiogram, blood pressure, or body temperature. With psychophysical measures no changes occurred in pain thresholds or skin sensitivity as a function of drug treatment. In time estimates of the passage of 1 minute, Δ9 -THC alone produced underestimates of the passage of 1 minute and CBN alone had no effect. In combination the two drugs had a tendency to produce significant overestimates and underestimates of the passage of 1 minute. On a 66-item adjective-pair drug reaction scale, the volunteers reported feeling drugged, drunk, dizzy, and drowsy under the Δ9 -THC condition, but not under the CBN condition. With combined drug treatment, volunteers reported feeling more drugged, drunk, dizzy, and drowsy than under the Δ9-THC condition alone. None of the drug treatments produced significant changes on other items which included items on perception, emotion, cognition and sociability. It appears that CBN increases the effect of Δ9-THC on some aspects of physiological and psychological processes, but that these effects are small and cannot account for the greater potency which has been reported when plant material is used.



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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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