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Table of Contents
Vol. 26, No. 1, 2008
Issue release date: July 2008

High Tofu Intake Is Associated with Worse Memory in Elderly Indonesian Men and Women

Hogervorst E. · Sadjimim T. · Yesufu A. · Kreager P. · Rahardjo T.B.
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Abstract

Background/Aims: Cell culture studies suggest that phytoestrogens, abundant in soy products such as tempe and tofu, could protect against cognitive decline. Paradoxically, the Honolulu Asia Aging Study reported an increased risk for cognitive impairment and other dementia markers with high tofu (soybean curd) intake. Methods: A cross-sectional study was carried out in 2 rural sites (Borobudur and Sumedang) and 1 urban site (Jakarta) among mainly Javanese and Sundanese elderly (n = 719, 52–98 years of age). Memory was measured using a word learning test sensitive to dementia and soy consumption was assessed using Food Frequency Questionnaire items. Results: High tofu consumption was associated with worse memory (β = –0.18, p < 0.01, 95% CI = –0.34 to –0.06), while high tempe consumption (a fermented whole soybean product) was independently related to better memory (β = 0.12, p < 0.05, 95% CI = 0.00–0.28), particularly in participants over 68 years of age. Fruit consumption also had an independent positive association. The analyses were controlled for age, sex, education, site and intake of other foods. Conclusion: The results for tofu consumption as a risk factor for low memory function may tie in with the Honolulu Asia Aging Study data. It is unclear whether these negative associations could be attributed to potential toxins or to its phytoestrogen levels. Estrogen (through which receptors phytoestrogens can exert effects) was found to increase dementia risk in women over 65 years of age. Tempe contains high levels of phytoestrogens, but (due to fermentation) also exhibits high folate levels which may exert protective effects. Future studies should validate these findings and investigate potential mechanisms.



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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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References

  1. Wang H, Murphy PA: Isoflavone content in commercial soybean products. J Agric Food Chem 1994;42:1666–1673.
  2. Mishra SI, Dickerson V, Najm W: Phytoestrogens and breast cancer prevention: what is the evidence? Am J Obstet Gynecol 2003;188(suppl 5):S66–S70.

    External Resources

  3. Hogervorst E: The short-lived effects of hormone replacement therapy on cognitive function; in: Rasgun NL (ed): Effects of Estrogen on Brain Function. Baltimore, John Hopkins University Press, 2006, pp 46–78.
  4. Zhao L, Chen Q, Diaz Brinton R: Neuroprotective and neurotrophic efficacy of phytoestrogens in cultured hippocampal neurons. Exp Biol Med (Maywood) 2002;227:509–519.
  5. Bu L, Lephart ED: Soy isoflavones modulate the expression of BAD and neuron-specific beta III tubulin in male rat brain. Neurosci Lett 2005;385:153–157.
  6. White LR, Petrovitch H, Ross GW, Masaki K, Hardman J, Nelson J, et al: Brain aging and midlife tofu consumption. J Am Coll Nutr 2000;19:242–255.
  7. Henderson VW: Hormone therapy and Alzheimer’s disease: benefit or harm? Expert Opin Pharmacother 2004;5:389–406.
  8. Gibbs RB: The effects of estrogen in animal models; in: Rasgun NL (ed): Effects of Estrogen on Brain Function. Baltimore, John Hopkins University Press, 2006, pp 9–45.
  9. Hogervorst E, Bandelow S: Should surgical menopausal women be treated with estrogens to decrease the risk of dementia? Neurology 2007;69:1070–1071.
  10. Yesufu A, Bandelow S, Hogervorst E: Meta-analyses of the effect of hormone treatment on cognitive function in postmenopausal women. Womens Health 2007;3:173–194.
  11. Frankenfeld CL, Lampe JW, Shannon J, Gao DL, Ray RM, Prunty J, et al: Frequency of soy food consumption and serum isoflavone concentrations among Chinese women in Shanghai. Public Health Nutr 2004;7:765–772.
  12. Barberger-Gateau P, Raffaitin C, Letenneur L, Berr C, Tzourio C, Dartigues JF, et al: Dietary patterns and risk of dementia: the Three-City cohort study. Neurology 2007;69:1921–1930.
  13. Brandt J: The Hopkins Verbal Learning Test: development of a new memory test with six equivalent forms. Clin Neuropsychol 1991;5:125–142.
  14. Schrijnemaekers AM, de Jager CA, Hogervorst E, Budge MM: Cases with mild cognitive impairment and Alzheimer’s disease fail to benefit from repeated exposure to episodic memory tests as compared with controls. J Clin Exp Neuropsychol 2006;28:438–455.
  15. De Jager CA, Hogervorst E, Combrinck M, Budge MM: Sensitivity and specificity of neuropsychological tests for mild cognitive impairment, vascular cognitive impairment and Alzheimer’s disease. Psychol Med 2003;33:1039–1050.
  16. Hogervorst E, Combrinck M, Lapuerta P, Rue J, Swales K, Budge M: The Hopkins Verbal Learning Test and screening for dementia. Dement Geriatr Cogn Disord 2002;13:13–20.
  17. Frankenfeld CL, Patterson RE, Horner NK, Neuhouser ML, Skor HE, Kalhorn TF, et al: Validation of a soy food frequency questionnaire and evaluation of correlates of plasma isoflavone concentrations in postmenopausal women. Am J Clin Nutr 2003;77:674–680.
  18. Petitti DB, Buckwalter JG, Crooks VC, Chiu V: Prevalence of dementia in users of hormone replacement therapy as defined by prescription data. J Gerontol A Biol Sci Med Sci 2002;57:M532–M538.
  19. Frank B, Gupta S: A review of antioxidants and Alzheimer’s disease. Ann Clin Psychiatry 2005;17:269–286.
  20. Paoletti AM, Congia S, Lello S, Tedde D, Orru M, Pistis M, et al: Low androgenization index in elderly women and elderly men with Alzheimer’s disease. Neurology 2004;62:301–303.
  21. Cunningham CJ, Sinnott M, Denihan A, Rowan M, Walsh JB, O’Moore R, et al: Endogenous sex hormone levels in postmenopausal women with Alzheimer’s disease. J Clin Endocrinol Metab 2001;86:1099–1103.
  22. Hogervorst E, Williams J, Budge M, Barnetson L, Combrinck M, Smith AD: Serum total testosterone is lower in men with Alzheimer’s disease. Neuro Endocrinol Lett 2001;22:163–168.
  23. Den Heijer T, Geerlings MI, Hofman A, de Jong FH, Launer LJ, Pols HA, et al: Higher estrogen levels are not associated with larger hippocampi and better memory performance. Arch Neurol 2003;60:213–220.
  24. Ginting E, Arcot J: High-performance liquid chromatographic determination of naturally occurring folates during tempe preparation. J Agric Food Chem 2004;52:7752–7758.
  25. Hogervorst E, Smith AD: The interaction of serum folate and estradiol levels in Alzheimer’s disease. Neuro Endocrinol Lett 2002;23:155–160.
  26. Smith AD: Homocysteine, B vitamins, and cognitive deficit in the elderly. Am J Clin Nutr 2002;75:785–786.
  27. Gurel A, Coskun O, Armutcu F, Kanter M, Ozen OA: Vitamin E against oxidative damage caused by formaldehyde in frontal cortex and hippocampus: biochemical and histological studies. J Chem Neuroanat 2005;29:173–178.
  28. Rilantono LI, Yuwono HS, Nugrahadi T: Dietary antioxidative potential in arteries. Clin Hemorheol Microcirc 2000;23:113–117.


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