Journal Mobile Options
Table of Contents
Vol. 76, No. 5, 1999
Issue release date: November 1999

Prenatal Stress and Immune Recognition of Self and Nonself in the Primate Neonate

Coe C.L. · Lubach G.R. · Karaszewski J.W.
To view the fulltext, log in and/or choose pay-per-view option

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Abstract

The capacity of the neonate to respond to nonself antigens was evaluated in infant monkeys born after normal and disturbed pregnancies. Mixed lymphocyte cultures were used to test the infants’ proliferative responses to mitomycin-treated stimulator cells, either from a genetically unrelated animal or from a virally transformed monkey cell line. Periods of daily stress for 6 weeks in mid-late pregnancy (months 3.0–4.5) resulted in a significant decrease in proliferative responses, whereas the same stressor early in pregnancy (months 1.5–3.0) increased responses by the neonate’s cells. Similar to the late stress effect, an inhibition of proliferative responses by neonatal cells was induced by dexamethasone administered for 2 days late in pregnancy at 4.5 months after conception, 1 month before term. These findings demonstrate that certain immune responses at birth are extremely sensitive to prior prenatal events. Further, the bidirectional changes indicate that there may be critical periods in gestation when the same extrinsic events have radically different effects on the fetus.



Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Bakker JM, Donne-Smidt E, Kavelaars A, Heijnen CJ, Tildres FJH, Van Rees EP: Effects of short-term dexamethasone treatment during pregnancy on the development of the immune system and the hypothalamo-pituitary-adrenal axis in the rat. J Neuroimmunol 1995;63:183–192.
  2. Eishi Y, Hirokawa K, Hatakeyama S: Long-lasting impairment of immune and endocrine systems of offspring induced by injection of dexamethasone into pregnant mice. Clin Immunol Immunopathol 1983;26:334–349.
  3. Klein SL, Rager DR: Prenatal stress alters immune function in the offspring of rats. Dev Psychobiol 1995;28:321–326.
  4. Murphy KK, Moya FR: Effect of betamethasone on maternal, fetal, and neonatal rat cellular immunity. Early Hum Dev 1994;36:1–11.
  5. Kay G, Tarcic N, Poltyrev T, Weinstock M: Prenatal stress depresses immune function in rats: Physiol Behav 1998;63:397–402.
  6. Cederqvist LL, Ylikorkala FO, Ekelund L, Tuimala R, Litwin SD: Fetal immunoglobulin production following prenatal glucocorticoid treatment. Obstet Gynecol 1978;52:539–541.

    External Resources

  7. Kauppila A, Hartikainen-Sorri AL, Koivisto M, Ryhanen P: Cell-mediated immunocompetence of children exposed in utero to short- or long-term action of glucocorticoids. Gynecol Obstet Invest 1983;15:41–48.

    External Resources

  8. Smolders-de Haas H, Neuvel J, Schmand B, Terffers PE, Koppe JG, Hoeks J: Physical development and medical history of children who were treated antenatally with corticosteroids to prevent respiratory distress syndrome: A 10- to 12-year follow-up. Pediatrics 1990;86:65–70.
  9. Schneider ML, Roughton EC, Koehler AJ, Lubach GR: Growth and development following prenatal stress exposure in primates: An examination of ontogenetic vulnerability. Child Dev 1999;70:263–274.

    External Resources

  10. Coe CL, Lubach GR, Schneider ML: Neuromotor and socio-emotional behavior in the young monkey are presaged by prenatal conditions; in Lewis M (ed): Stress and Soothing. Hillsdale, Erlbaum, 1999, pp 19–38.
  11. Schneider ML, Coe CL, Lubach GR: Endocrine activation mimics the adverse effects of prenatal stress on the neuromotor development of the infant primate. Dev Psychobiol 1992;25:427–439.

    External Resources

  12. Coe CL, Lubach GR, Karaszewski JW, Ershler WB: Prenatal endocrine activation alters postnatal cellular immunity in infant monkeys. Brain Behav Immun 1996;10:221–234.

    External Resources

  13. Kavelaars A, van der Pompe G, Bakker JM, van Hasselt PM, Cats B, Visser GHA, Heijnen CJ: Altered immune function in human newborns after prenatal administration of betamethasone: Enhanced natural killer cell activity and decreased T cell proliferation in cord blood. Pediatr Res 1999;45:306–312.
  14. Heise ER, Manning CH, McMahan MR, Keever CA: Mixed lymphocyte reactions in Macaca fascicularis. J Med Primatol 1991;20:67–74.
  15. Seghaye MC, Heyl W, Grabitz RG, Schumacher K, von Bernuth G, Rath W, Duchateau J: The production of pro- and anti-inflammatory cytokines in neonates assessed by stimulated whole cord blood culture and by plasma levels at birth. Biol Neonate 1998;73:220–227.
  16. Voss G, Nick S, Stahl-Hennig C, Ritter K, Hunsmann G: Generation of macaque B lymphoblastoid cell lines with simian Epstein-Barr-like viruses: Transformation procedure, characterization of the cell lines and occurrence of simian foamy virus. J Virol Methods 1992;39:185–195.
  17. Li R, Haas JD, Habicht JP: Timing of the influence of maternal nutritional status during pregnancy on fetal growth. Am J Hum Biol 1998;10:529–539.

    External Resources

  18. Jones AC, Burdge GC, Warner JA, Postle AD, Warner JO: Ontogeny of circulating leucocytes in the fetal guinea pig. Biol Neonate 1996;70:108–115.
  19. Johnson JWC, Mitzner W, London WT, Palmer AE, Scott R: Betamethasone and the rhesus fetus: Multisystemic effects. Am J Obstet Gynecol 1979;133:677–684.

    External Resources

  20. Sawyer R, Hendrickx A, Osburn B, Terrell T: Abnormal morphology of the fetal monkey (Macaca mulatta) thymus exposed to a corticosteroid. J Med Primatol 1977;6:145–150.

    External Resources

  21. Uno H, Lohmiller L, Thieme C, Kemnitz JW, Engle MJ, Roecker EB, Farrell PM: Brain damage induced by prenatal exposure to dexamethasone in fetal rhesus macaques. I. Hippocampus. Brain Res Dev Brain Res 1990;53:157–167.
  22. Coe CL, Kemnitz JW, Schneider ML: Vulnerability of placental antibody transfer and fetal complement synthesis to disturbance of the pregnant monkey. J Med Primatol 1993;22:294–300.
  23. Novy MJ, Walsh SW: Dexamethasone and estradiol treatment in pregnant rhesus macaques: Effects on gestational length, maternal plasma hormones, and fetal growth. Am J Obstet Gynecol 1983;145:920–930.
  24. Jobe AH, Wad H, Berry LM, Ikegami M, Ervin MG: Single and repetitive maternal glucocorticoid exposures reduce fetal growth in sheep. Gen Obstet Gynecol 1998;178:880–885.
  25. Derks JB, Mulder EJH, Visser GHA: The effects of maternal betamethasone administration on the fetus. Br J Obstet Gynaecol 1995;102:40–46.
  26. Kavelaars A, Cats B, Visser GHA, Zegers BJM, Bakker JM, van Rees EP, Heijnen CJ: Ontogeny of the response to human peripheral blood T cells to glucocorticoids. Brain Behav Immun 1996;10:288–297.

    External Resources

  27. Shenoy M, MacPherson B, Christadoss P: Suramin inhibits the mixed lymphocyte reaction by suppressing lymphokine production. J Clin Immunol 1992;12:122–129.

    External Resources

  28. Moudgil A, Toyoda M, Galfayan K, Jordan SC: Selective expression of the interleukin-2 gene discriminates between the auto- and allo-mixed lymphocyte reaction. Transpl Immunol 1997;5:35–38.

    External Resources

  29. Splawski JB, Jelinek DF, Lipisky PE: Delineation of the functional capacity of human neonatal lymphocytes. J Clin Invest 1991;87:545–553.

    External Resources

  30. Watson W, Oen K, Ramdahin R, Harman C: Immunoglobulin and cytokine production by neonatal lymphocytes. Clin Exp Immunol 1991;83:169–174.


Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50