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Vol. 78, No. 2, 2000
Issue release date: August 2000

High Prevalence of Factor V Leiden Mutation in Mothers of Premature Neonates

Erhardt E. · Stankovics J. · Molnár D. · Adamovich K. · Melegh B.
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Abstract

The prevalence of the Leiden mutation was tested in 50 mothers of premature infants and in 56 mothers of intrauterine-growth-retarded neonates. The prevalence of the Leiden mutation was 7.2% in the mothers of growth-retarded neonates and 18% in the group of mothers of premature infants, the latter being significantly higher than the 6.3% prevalence of this mutation in healthy Hungarian subjects (p < 0.01). In spite of the relatively small number of mothers examined, the unexpected finding may call attention to a hitherto unknown relationship.

Copyright © 2000 S. Karger AG, Basel



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References

  1. Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Veiden PA, Reitsma PH: Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994;369:64–67.
  2. Lindqvist PG, Svensson PJ, Dahlbäck B, Marsal K: Factor V Q506 mutation (activated protein C resistance) associated with reduced blood loss – A possible evolutionary selection mechanism. Thromb Haemost 1998;79:69–73.
  3. Zöller B, Dahlbäck B: Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis. Lancet 1994;343:1536.
  4. SPSS 7.5 for Windows, Standard Version. Chicago, Ill., SPSS Inc, 1995.
  5. Melegh B, Stankovics J, Kis A, Nagy J, Losonczy H, Méhes K: Increased prevalence of factor V Leiden mutation in neonatal intracranial haemorrhage. Eur J Pediatr 1998;157:261.
  6. Rees DC, Cox M, Clegg JB: World distribution of factor V Leiden. Lancet 1995;346:1133–1134.


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