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Vol. 94, No. 3, 2008
Issue release date: October 2008
Section title: Systematic Review and Meta-Analysis
Neonatology 2008;94:176–182
(DOI:10.1159/000143397)

Resuscitation of Newborn Infants with 21% or 100% Oxygen: An Updated Systematic Review and Meta-Analysis

Saugstad O.D. · Ramji S. · Soll R.F. · Vento M.
aDepartment of Paediatric Research, Rikshospitalet Medical Centre, University of Oslo, Oslo, Norway; bDepartment of Paediatrics, Maulana Azad Medical College, New Delhi, India; cDepartment of Pediatrics, University of Vermont College of Medicine, Burlington, Vt., USA; dServicio de Neonatologia, Hospital Universitario Materno-Infantil, La Fe, Valencia, Spain

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Article / Publication Details

First-Page Preview
Abstract of Systematic Review and Meta-Analysis

Published online: 7/9/2008

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Background: The issue of whether 21% O2 is more effective than 100% O2 for resuscitation of newborn infants remains controversial. Objectives: We have updated the systematic review and meta-analysis including all studies reporting resuscitation of newborn infants with 21 or 100% O2. Methods: Randomized or quasi-randomized studies of depressed newborn infants resuscitated with 21 or 100% O2 with or without masking of treatment were considered for inclusion. The outcomes of interest included neonatal mortality and hypoxic ischemic encephalopathy. Results: Ten studies fulfilled the inclusion criteria. Of these, 6 studies were identified as being strictly randomized. In total, 1,082 infants were allocated to resuscitation with 21% O2 and 1,051 infants with 100% O2. The risk of neonatal mortality was reduced in the 21% O2 group compared to the 100% O2 group both in the analysis of all studies (typical RR 0.69, 95% CI 0.54, 0.88) and in the analysis of strictly randomized studies (typical RR 0.32, 95% CI 0.12, 0.84). A trend toward a decrease in the risk of hypoxic ischemic encephalopathy stage 2 and 3 was noted with resuscitation in 21% O2 in the analysis of all studies (typical RR 0.88, 95% CI 0.72, 1.08). Conclusions: There is a significant reduction in the risk of neonatal mortality and a trend towards a reduction in the risk of severe hypoxic ischemic encephalopathy in newborns resuscitated with 21% O2.


Article / Publication Details

First-Page Preview
Abstract of Systematic Review and Meta-Analysis

Published online: 7/9/2008

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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