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Table of Contents
Vol. 7, No. 2, 1998
Issue release date: March–April 1998
Biol Signals Recept 1998;7:125–135
(DOI:10.1159/000014538)

Lipid Modifications and Membrane Targeting of Gα

Wedegaertner P.B.
Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pa., USA

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Abstract

G protein α-subunits (Gα) undergo palmitoylation and/or myristoylation. This review will focus on new insights into the function and regulation of these fatty acid modifications of Gα. Most importantly, I will examine lipid modifications of Gα in the context of a two-signal model for membrane attachment, discuss recent advances in the identification of palmitoyl transferases, and highlight several controversial issues in this field.



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