G protein α-subunits (Gα) undergo palmitoylation and/or myristoylation. This review will focus on new insights into the function and regulation of these fatty acid modifications of Gα. Most importantly, I will examine lipid modifications of Gα in the context of a two-signal model for membrane attachment, discuss recent advances in the identification of palmitoyl transferases, and highlight several controversial issues in this field.
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