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Vol. 9, No. 5, 2000
Issue release date: September–October 2000
Biol Signals Recept 2000;9:260–266
(DOI:10.1159/000014648)

Melatonin and Melanocyte Functions

Iyengar B.
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Abstract

The effect of melatonin on melanocyte functions was studied by incubating whole-skin organ cultures with melatonin, as well as by assessing melatonin positivity in melanocytes versus dendricity and pigmentation, when arrested in the G2 phase. From this study, it was observed that melatonin positivity is inversely related to the length of UV exposure. Increasing melatonin levels are related to decreasing dendricity and pigment donation during photoresponse in the G2 phase. Melanocyte melatonin positivity increases with dark incubation and is higher with a pulse of UV exposure after dark incubation with melatonin. This increase is associated with a doubling of melanocyte number after dark incubation and a further doubling upon exposure to a pulse of UV. The melanocytes directly take up melatonin, which results in a marked increase in their numbers. Thus, extreme caution should be exercised when using melatonin as an anticancer drug. This finding also simulates the melanocyte repopulation of the skin with repigmentation during summer in polar animals.

Copyright © 2000 S. Karger AG, Basel



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References

  1. Lerner AB, Case JD, Takahashi Y, Lee TH, Mori W: Isolation of melatonin, the pineal factor that lightens melanocytes. J Am Chem Soc 1958;80:2587.
  2. Armstrong SM: Melatonin and circadian control in mammals. Experientia 1989;45:932–938.

    External Resources

  3. Iyengar B, Timar J, Szende B: Modulation of cell cycle traverse in the amelanotic melanocytes of vitiligo and melanomas. The interphase between aplasia and neoplasia; in Iyengar B, Singh AV (eds): Growth Disorders of the Pigment Cell. Churchill Livingstone, New Delhi, pp 220–234.
  4. Iyengar B: The UV-responsive melanocyte system: A peripheral network for photoperiodic time measurements. A function of indoleamine expression. Acta Anat (Basel) 1998;163:173–178.
  5. Iyengar B: Indoleamines and the UV-light-sensitive photoperiodic responses of the melanocyte network: A biological calender? Experientia 1994;50:733–736.

    External Resources

  6. Iyengar B: Photomodulation of the melanocyte cell cycle by indoleamines. Biol Signals Recept 1998;7:345–350.
  7. Gaudet SJ, Slominski A, Etminan H, Pruski D, Paus R, Nambodiri MAA: Identification and characterisation of two isozymic forms of arylamine N-acetyl-transferase in Syrian hamster skin. J Invest Dermatol 1993;101:660–665.
  8. Slominski A, Baker J, Rosano TG, Guisti LW, Ermak G, Grande M, Gaudet SJ: Metabolism of serotonin to N-acetylserotonin, melatonin and 5-methoxytryptamine in hamster skin culture. J Biol Chem 1996;271:12281–12286.
  9. Iyengar B: Pathology of marginal melanocytes in vitiligo; in Iyengar B, Singh AV (eds): Growth Disorders of the Pigment Cell. New Delhi, Churchill Livingstone, 1996, pp 58–62.
  10. Slominski A, Paus R, Bomirski A: Hypothesis: Possible role for the melatonin receptor in vitiligo: Discussion paper. J R Soc Med 1989;82:539–541.

    External Resources

  11. Pearse AGE: Histochemistry, ed 4. Edinburgh, Churchill Livingstone, 1980.
  12. Iyengar B: Corticotropin expression by human melanocytes in skin. Pigment Cell Res 1995;8:142–146.
  13. Sugden D: Melatonin biosynthesis in the mammalian pineal gland. Experientia 1989;45:922–932.

    External Resources

  14. Underwood H: The pineal and melatonin: Regulators of circadian function in lower vertebrates. Experientia 1989;45:914–922.
  15. Slominski A, Pruski D: Melatonin inhibits proliferation and melanogenesis in rodent melanoma cells. Exp Cell Res 1993;206:189–194.
  16. Benitez-King G, Anton-Fay: Calmodulin mediates melatonin cytoskeletal effects. Experientia, 1993;49:635–641.
  17. Morita M, Best JB: The occurrence and physiological functions of melatonin in the most primitive eumetazoans, the planarians. Experientia 1993;49:623.


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