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Neuroimmunomodulation 2008;15:102–107

Innate Immune Markers in Mothers and Fathers of Children Newly Diagnosed with Cancer

Lutz Stehl M.J.a · Kazak A.E.a, b · Hwang W.-T.c · Pai A.L.H.a · Reilly A.F.a, b · Douglas S.D.d
aDivision of Oncology, The Children’s Hospital of Philadelphia, Departments of bPediatrics and cBiostatistics and Epidemiology, University of Pennsylvania School of Medicine, and dDivision of Allergy-Immunology, The Joseph Stokes Jr. Research Institute at The Children’s Hospital of Philadelphia, Philadelphia, Pa., USA
email Corresponding Author

 goto top of outline Key Words

  • Pediatric cancer
  • Natural killer cell
  • Immune function
  • Caregivers
  • Acute stress

 goto top of outline Abstract

Objective: The diagnosis of a life-threatening illness in a child is one of the most stressful events imaginable for parents and is associated with increased anxiety and distress. Despite associations between stress and immune function in animal and human models, the immune function in caregivers of children at the time of a child-related potentially traumatic event, like cancer, is not known. Methods: Nineteen parents (11 mothers, 8 fathers), representing six caregiver pairs, provided blood for natural killer (NK) cell count by flow cytometry and function assays [% NK whole blood, absolute NK whole blood, LU20 (lytic unit) peripheral blood mononuclear cells, LU20 NK cells] and completed self-report measures (acute stress) within 2 weeks of learning their child had cancer. The NK cell assay was also completed with a sample of healthy adults, the immune reference group. Results: There were similar levels of NK cell activity between caregivers and the immune reference group. Immune level and psychological outcomes were not associated. LU20 peripheral blood mononuclear cells and LU20 NK cells were each correlated at r = 0.83 between mothers and fathers in the same family. Conclusions: Although based on a small sample, these preliminary results suggest that knowledge about stress responses in parents of children with life-threatening illness may be important and provide novel data regarding the shared impact of stress on immune function within caregiver dyads.

Copyright © 2008 S. Karger AG, Basel

 goto top of outline References
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 goto top of outline Author Contacts

Dr. Anne E. Kazak
The Children’s Hospital of Philadelphia
34th Street and Civic Center Boulevard, Room 1486, CHOP North
Philadelphia, PA 19104-4399 (USA)
Tel. +1 215 590 2220, Fax +1 215 590 3020, E-Mail

 goto top of outline Article Information

Received: October 17, 2007
Accepted: March 12, 2008
Published online: August 5, 2008
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 2, Number of References : 23

 goto top of outline Publication Details


Vol. 15, No. 2, Year 2008 (Cover Date: August 2008)

Journal Editor: Savino W. (Rio de Janeiro)
ISSN: 1021–7401 (Print), eISSN: 1423–0216 (Online)

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