Journal Mobile Options
Table of Contents
Vol. 13, No. 6, 2008
Issue release date: October 2008
Section title: Original Paper
Audiol Neurotol 2008;13:396–404
(DOI:10.1159/000148203)

Ocular Vestibular Evoked Myogenic Potentials in Response to Bone-Conducted Vibration of the Midline Forehead at Fz

A New Indicator of Unilateral Otolithic Loss

Iwasaki S. · Smulders Y.E. · Burgess A.M. · McGarvie L.A. · MacDougall H.G. · Halmagyi G.M. · Curthoys I.S.
aDepartment of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan; bFaculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands; cVestibular Research Laboratory, School of Psychology, University of Sydney, and dDepartment of Neurology, Royal Prince Alfred Hospital, Sydney, N.S.W., Australia

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restriction apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/12/2007
Accepted: 4/17/2008
Published online: 7/29/2008

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 1

ISSN: 1420-3030 (Print)
eISSN: 1421-9700 (Online)

For additional information: http://www.karger.com/AUD

Abstract

If a patient, who is lying supine and looking upward, is given bone-conducted vibration (BCV) of the forehead at the hairline in the midline (Fz) with a clinical reflex hammer or a powerful bone conduction vibrator, short-latency surface potentials called ocular vestibular evoked myogenic potentials (oVEMP) can be recorded from just beneath the eyes. The early negative (excitatory) component (n10) is approximately equal in amplitude for both eyes in healthy subjects, but in patients with unilateral vestibular loss, the n10 component is significantly asymmetrical under the 2 eyes – the n10 component is small or absent under the eye on the side contralateral to the prior unilateral vestibular nerve removal, but of normal amplitude under the eye on the side contralateral to the healthy ear. The n10 component of the oVEMP response to BCV at Fz stimuli reflects vestibular and probably mainly otolithic function via crossed otolithic-ocular pathways, and so n10 asymmetry is a new way of identifying the affected side in patients with unilateral otolithic loss.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/12/2007
Accepted: 4/17/2008
Published online: 7/29/2008

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 1

ISSN: 1420-3030 (Print)
eISSN: 1421-9700 (Online)

For additional information: http://www.karger.com/AUD


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Colebatch JG, Halmagyi GM, Skuse NF: Myogenic potentials generated by a click-evoked vestibulocollic reflex. J Neurol Neurosurg Psychiatry 1994;57:190–197.
  2. Colebatch JG, Rothwell JC: Motor unit excitability changes mediating vestibulocollic reflexes in the sternocleidomastoid muscle. Clin Neurophysiol 2004;115:2567–2573.
  3. Curthoys IS: Eye movements produced by utricular and saccular stimulation. Aviat Space Environ Med 1987;58:A192–A198.
  4. Curthoys IS, Halmagyi GM: Vestibular compensation: a review of the oculomotor, neural, and clinical consequences of unilateral vestibular loss. J Vestib Res 1995;5:67–107.
  5. Curthoys IS, Kim J, McPhedran SK, Camp AJ: Bone conducted vibration selectively activates irregular primary otolithic vestibular neurons in the guinea pig. Exp Brain Res 2006;175:256–267.
  6. Goldberg JM: Afferent diversity and the organization of central vestibular pathways. Exp Brain Res 2000;130:277–297.
  7. Goto F, Meng H, Bai R, Sato H, Imagawa M, Sasaki M, Uchino Y: Eye movements evoked by selective saccular nerve stimulation in cats. Auris Nasus Larynx 2004;31:220–225.
  8. Halmagyi GM, Curthoys IS, Colebatch JG, Aw ST: Vestibular responses to sound. Ann NY Acad Sci 2005;1039:54–67.
  9. Halmagyi GM, Yavor RA, Colebatch JG: Tapping the head activates the vestibular system: a new use for the clinical reflex hammer. Neurology 1995;45:1927–1929.
  10. Hess BJM, Dieringer N: Spatial organization of linear vestibuloocular reflexes of the rat: responses during horizontal and vertical linear acceleration. J Neurophysiol 1991;66:1805–1818.
  11. Hwang JC, Poon WF: An electrophysiological study of the sacculo-ocular pathways in cats. Jap J Physiol 1975;25:241–251.
  12. Iwasaki S, McGarvie LA, Halmagyi GM, Burgess AM, Kim J, Colebatch JG, Curthoys IS: Head taps evoke a crossed vestibulo-ocular reflex. Neurology 2007;68:1227–1229.
  13. Iwasaki S, Smulders YE, Burgess AM, McGarvie LA, MacDougall HG, Halmagyi GM, Curthoys IS: Ocular vestibular evoked myogenic potentials to bone conducted vibration of the midline forehead at Fz in healthy subjects. Clin Neurophysiol DOI 10.1016/j.clinph.2008.05.028.
  14. Jombik P, Bahyl V: Short latency responses in the averaged electro-oculogram elicited by vibrational impulse stimuli applied to the skull: could they reflect vestibulo-ocular reflex function? J Neurol Neurosurg Psychiatry 2005a;76:222–228.
  15. Jombik P, Bahyl V: Short latency disconjugate vestibulo-ocular responses to transient stimuli in the audio frequency range. J Neurol Neurosurg Psychiatry 2005b;76:1398–1402.
  16. Kushiro K, Zakir M, Sato H, Ono S, Ogawa Y, Meng H, Zhang X, Uchino Y: Saccular and utricular inputs to single vestibular neurons in cats. Exp Brain Res 2000:131:406–415.
  17. McCue MP, Guinan JJ Jr: Acoustically responsive fibers in the vestibular nerve of the cat. J Neurosci 1994;14:6058–6070.
  18. Murofushi T, Curthoys IS, Topple AN, Colebatch JG, Halmagyi GM: Responses of guinea pig primary vestibular neurons to clicks. Exp Brain Res 1995;103:174–178.
  19. Murofushi T, Halmagyi GM, Yavor RA, Colebatch JG: Absent vestibular evoked myogenic potentials in vestibular neurolabyrinthitis: an indicator of inferior vestibular nerve involvement? Arch Otolaryngol Head Neck Surg 1996;122:845–848.
  20. Oostenveld R, Praamstra P: The five percent electrode system for high-resolution EEG and ERP measurements. Clin Neurophysiol 2001;112:713–719.
  21. Raphan T, Matsuo V, Cohen B: Velocity storage in the vestibulo-ocular reflex arc (VOR) Exp Brain Res 1979;35:229–248.
  22. Rosengren SM, Todd NPM, Colebatch JG: Vestibular-evoked extraocular potentials produced by stimulation with bone-conducted sound. Clin Neurophysiol 2005;116:1938–1948.
  23. Schmid-Priscoveanu A, Straumann D, Bohmer A, Obzina H: Vestibulo-ocular responses during static head roll and three-dimensional head impulses after vestibular neuritis. Acta Otolaryngol 1999;119:750–757.
  24. Suzuki JI, Tokumasu K, Goto K: Eye movements from single utricular nerve stimulation in the cat. Acta Otolaryngol 1969;68:350–362.
  25. Szentagothai J: Die Rolle der einzelnen Labyrinthrezeptoren bei der Orientation von Augen und Kopf im Raume. Budapest, Akad. Kiado, 1952.
  26. Todd NPM, Rosengren SM, Aw ST, Colebatch JG: Ocular vestibular evoked myogenic potentials (OVEMPs) produced by air- and bone-conducted sound. Clin Neurophysiol 2007;118:381–390.
  27. Tsubota M, Shojaku H, Hori E, Fujisaka M, Hayashi N, Kurimoto M, Hatakeyama N, Yamazaki M, Nishijo H, Ono T, Yamamoto H, Watanabe Y: Effects of vestibular nerve section on sound-evoked myogenic potentials in the sternocleidomastoid muscle of monkeys. Clin Neurophysiol 2007;118:1488–1493.
  28. Uchino Y, Sasaki M, Sato H, Bai R, Kawamoto E: Otolith and canal integration on single vestibular neurons in cats. Exp Brain Res 2005;164:271–285.
  29. Welgampola MS: Evoked potential testing in neuro-otology. Curr Opin Neurol 2008;21:29–35.
  30. Welgampola MS, Colebatch JG: Characteristics and clinical applications of vestibular-evoked myogenic potentials. Neurology 2005;64:1682–1688.
  31. Winer BJ, Brown DR, Michels KM: Statistical Principles in Experimental Design. New York, McGraw Hill, 1991.
  32. Young ED, Fernandez C, Goldberg JM: Responses of squirrel monkey vestibular neurons to audio-frequency sound and head vibration. Acta Otolaryngol 1977;84:352–360.