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Vol. 81, No. 3-4, 1998
Issue release date: 1998
Cytogenet Cell Genet 81:275–277 (1998)

The INSL4 gene maps close to WI-5527 at 9p24.1→p23.3 clustered with two relaxin genes and outside the critical region for the monosomy 9p syndrome

Veitia R. · Laurent A. · Quintana-Murci L. · Ottolenghi C. · Fellous M. · Vidaud M. · McElreavey K.
aUnité d’Immunogénétique Humaine, Institut Pasteur; bLaboratoire de Génétique Moléculaire, Université René Descartes-Paris V, Faculté des Sciences Pharmaceutiques et Biologiques de Paris, Paris (France); cDipartimento di Morfologia ed Embriologia, Facoltà di Medicina, Università di Ferrara, Ferrara (Italy)

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The insulin like growth factor 4 (INSL4) gene belongs to the insulin gene superfamily and has been mapped by fluorescent in situ hybridization to 9p24. Expression of INSL4, of unknown function, has been recently detected in the perichondrium and ligaments of the human embryo. Here we have mapped INSL4 within the framework of a partial YAC contig covering the distal part of 9p to find out whether this gene lies within the critical region defined for the monosomy 9p syndrome. The gene was also located using a human-rodent radiation hybrid panel. INSL4 was found to be distal to the del(9p) critical region and excluded as a candidate for the syndrome. In addition, the positions of two relaxin genes (RLN1, RLN2) that belong to the same superfamily as INSL4 and which have also been mapped to chromosome 9, were refined. We have shown that the three genes are clustered in the same region.

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  1. Alfi O, Donnell GN, Crandall BF, Derencsenyi A, Menon R: Deletion of the short arm of chromosome 9 (46, 9p–): A new deletion syndrome. Ann Génét (Paris) 16:17–22 (1973).
  2. Bouzyk M, Bryant SP, Evans C, Guioli S, Ford S, Schmidt K, Goodfellow PN, Povey S, Rebello M, Rousseaux S, Spurr NK: Integrated radiation hybrid and yeast artificial chromosome map of chromosome 9p. Eur J Hum Genet 5:299–307 (1997).
  3. Chassin D, Laurent A, Janneau J-L, Berger R, Bellet D: Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta. Genomics 29:465–470 (1995).
  4. Crawford RJ, Hudson P, Shine J, Niall HD, Eddy RL, Shows TB: Two relaxin genes are on chromosome 9. EMBO J 3:2341–2345 (1984).

    External Resources

  5. Evans BA, Fu P, Tregear GW: Characterization of two relaxin genes in the chimpanzee. J Endocr 140:385–392 (1994).

    External Resources

  6. Huret JL, Leonard C, Forestier B, Rethoré MO, Lejeune J: Eleven new cases of del (9p) and features from 80 cases. J Med Genet 25:741–749 (1988).
  7. Laurent A, Rouillac C; Delezoide AL, Giovangrandi Y, Vekemans M, Bellet D, Abitbol M, Vidaud M: INSL4 and IGF-II gene expression in human embryonic and trophoblastic tissues. Mol Reprod Develop (in press 1998).
  8. McRory J, Sherwood NM: Ancient divergence of insulin and insulin-like growth factor. DNA Cell Biol 16:939–949 (1997).

    External Resources

  9. Schwartz S, Crowe CA, Conroy JM, Haren JM, Micale MA, Becker LA: Chromosome breakage in 9p and delineation of the critical region for the 9p deletion syndrome. (Abstract) Ann Hum Genet 61:222 (1997).
  10. Veitia R, Nunes M, Brauner R, Doco-Fenzy M, Joanny-Flinois O, Jaubert F, Lortat-Jacob S, Fellous M, McElreavey K: Deletions of distal 9p associated with 46,XY male to female sex reversal. Definition of the breakpoints at 9p23.3→9p24.1. Genomics 41:271–274 (1997).

    External Resources

  11. Veitia R, Nunes M, Quintana-Murci L, Rappaport R, Thibaud E, Jaubert F, Fellous M, McElreavey K, Gonçalves J, Silva M, Cidade Rodrigues J, Caspurro M, Boieiro F, Marques R, Lavinha J: Swyer syndrome and 46,XY partial gonadal dysgenesis associated with 9p deletions in absence of monosomy 9p syndrome. Am J hum Genet (in press 1998).
  12. Walter MA, Spillet DJ, Thomas P, Weissenbach J, Goodfellow PN: A method for constructing radiation hybrtid maps of whole genomes. Nature Genet 7:22–28 (1994).

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