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Vol. 83, No. 1-2, 1998
Issue release date: 1998
Cytogenet Cell Genet 83:90–92 (1998)
(DOI:10.1159/000015138)

The gene encoding the transcriptional repressor BERF-1 maps to a region of conserved synteny on mouse chromosome 16 and human chromosome 3 and a related pseudogene maps to mouse chromosome 8

Antona V. · Cammarata G. · De Gregorio L. · Dragani T.A. · Giallongo A. · Feo S.
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Abstract

Abstract.

We have recently identified and characterized a Kruppel-like zinc finger protein (BERF-1), that functions as a repressor of β enolase gene transcription. By interspecific backcross analysis the gene encoding BERF-1 was localized 4.7 cM proximal to the Mtv6 locus on mouse chromosome 16, and an isolated pseudogene was localized to mouse chromosome 8, about 5.3 cM distal to the D8Mit4 marker. Nucleotide sequence identity and chomosome location indicate that the gene encoding BERF-1 is the mouse homologue (Zfp148) of ZNF148 localized to human chromosome 3q21, a common translocation site in acute myeloid leukemia patients.



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References

  1. Bernstein R, Bagg A, Pinto M, Lewis D, Mendelow B: Chromosome 3q21 abnormalities associated with hyperactive thrombopoiesis in acute blastic transformation of chronic myeloid leukemia. Blood 68:652–657 (1986).
  2. Feo S, Antona V, Barbieri G, Passantino R, Cali L, Giallongo A: Transcription of the human beta enolase gene (ENO-3) is regulated by an intronic muscle-specific enhancer that binds myocyte-specific enhancer factor 2 proteins and ubiquitous G-rich-box binding factors. Mol Cell Biol 15:5991–6002 (1995).

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  3. Hasegawa T, Takeuchi A, Miyaishi O, Isobe KI, de Crombrughe CB: Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes. J biol Chem 272:4915–4923 (1997).
  4. Law DJ, Tarlé SA, Merchant JL: The human ZBP-89 homolog located at chromosome 3q21 repress gastrin gene expression. Mammal Genome 9:165–167 (1998).
  5. Manenti G, Binelli G, Gariboldi M, Canzian F, De Gregorio L, Falvella FS, Dragani TA, Pierotti MA: Multiple loci affect genetic predisposition to hepatocarcinogenesis in mice. Genomics 23:118–124 (1994).
  6. Merchant JL, Iyer GR, Taylor BR, Kitchen JR, Mortensen ER, Wang Z, Flintoft RJ, Michel JB, Bassel-Duby R: ZBP-89 a Kruppel-like zinc finger protein inhibits epidermal growth factor induction of the gastrin promoter. Mol Cell Biol 16:6644–6653 (1996).

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  7. Passantino R, Antona V, Barbieri G, Rubino P, Melchionna R, Cossu G, Feo S, Giallongo A: Negative regulation of β enolase gene transcription in embryonic muscle is dependent upon a zinc finger factor that binds to the G-rich box within the muscle-specific enhancer. J biol Chem 273:484–494 (1998).
  8. Tommerup N, Vissing H: Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. Genomics 27:259–264 (1995).
  9. Yamagata N, Shimazaki C, Kikuta T, Hirai H, Sumikuma T, Sudo Y, Ashihara E, Goto H, Inaba T, Fujita N, Nakagawa M: A translocation between 3q21 and 12q24 in a patient with minimal differentiated acute myeloid leukemia (AML-M0). Cancer Genet Cytogenet 97:90–93 (1997).
  10. Wang Y, Kobori JA, Hood L: The htβ gene encodes a novel CACCC box-binding protein that regulates T-cell receptor gene expression. Mol Cell Biol 13:5691–5701 (1993).

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