Journal Mobile Options
Table of Contents
Vol. 83, No. 1-2, 1998
Issue release date: 1998
Cytogenet Cell Genet 83:90–92 (1998)

The gene encoding the transcriptional repressor BERF-1 maps to a region of conserved synteny on mouse chromosome 16 and human chromosome 3 and a related pseudogene maps to mouse chromosome 8

Antona V. · Cammarata G. · De Gregorio L. · Dragani T.A. · Giallongo A. · Feo S.
To view the fulltext, log in and/or choose pay-per-view option

Individual Users: Register with Karger Login Information

Please create your User ID & Password

Contact Information

I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in



We have recently identified and characterized a Kruppel-like zinc finger protein (BERF-1), that functions as a repressor of β enolase gene transcription. By interspecific backcross analysis the gene encoding BERF-1 was localized 4.7 cM proximal to the Mtv6 locus on mouse chromosome 16, and an isolated pseudogene was localized to mouse chromosome 8, about 5.3 cM distal to the D8Mit4 marker. Nucleotide sequence identity and chomosome location indicate that the gene encoding BERF-1 is the mouse homologue (Zfp148) of ZNF148 localized to human chromosome 3q21, a common translocation site in acute myeloid leukemia patients.

Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.


  1. Bernstein R, Bagg A, Pinto M, Lewis D, Mendelow B: Chromosome 3q21 abnormalities associated with hyperactive thrombopoiesis in acute blastic transformation of chronic myeloid leukemia. Blood 68:652–657 (1986).
  2. Feo S, Antona V, Barbieri G, Passantino R, Cali L, Giallongo A: Transcription of the human beta enolase gene (ENO-3) is regulated by an intronic muscle-specific enhancer that binds myocyte-specific enhancer factor 2 proteins and ubiquitous G-rich-box binding factors. Mol Cell Biol 15:5991–6002 (1995).

    External Resources

  3. Hasegawa T, Takeuchi A, Miyaishi O, Isobe KI, de Crombrughe CB: Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes. J biol Chem 272:4915–4923 (1997).
  4. Law DJ, Tarlé SA, Merchant JL: The human ZBP-89 homolog located at chromosome 3q21 repress gastrin gene expression. Mammal Genome 9:165–167 (1998).
  5. Manenti G, Binelli G, Gariboldi M, Canzian F, De Gregorio L, Falvella FS, Dragani TA, Pierotti MA: Multiple loci affect genetic predisposition to hepatocarcinogenesis in mice. Genomics 23:118–124 (1994).
  6. Merchant JL, Iyer GR, Taylor BR, Kitchen JR, Mortensen ER, Wang Z, Flintoft RJ, Michel JB, Bassel-Duby R: ZBP-89 a Kruppel-like zinc finger protein inhibits epidermal growth factor induction of the gastrin promoter. Mol Cell Biol 16:6644–6653 (1996).

    External Resources

  7. Passantino R, Antona V, Barbieri G, Rubino P, Melchionna R, Cossu G, Feo S, Giallongo A: Negative regulation of β enolase gene transcription in embryonic muscle is dependent upon a zinc finger factor that binds to the G-rich box within the muscle-specific enhancer. J biol Chem 273:484–494 (1998).
  8. Tommerup N, Vissing H: Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. Genomics 27:259–264 (1995).
  9. Yamagata N, Shimazaki C, Kikuta T, Hirai H, Sumikuma T, Sudo Y, Ashihara E, Goto H, Inaba T, Fujita N, Nakagawa M: A translocation between 3q21 and 12q24 in a patient with minimal differentiated acute myeloid leukemia (AML-M0). Cancer Genet Cytogenet 97:90–93 (1997).
  10. Wang Y, Kobori JA, Hood L: The htβ gene encodes a novel CACCC box-binding protein that regulates T-cell receptor gene expression. Mol Cell Biol 13:5691–5701 (1993).

    External Resources

Pay-per-View Options
Direct payment This item at the regular price: USD 33.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 23.00