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Vol. 72, No. 2, 2008
Issue release date: October 2008
Section title: Paper
Brain Behav Evol 2008;72:159–167
(DOI:10.1159/000151475)

Functional Tradeoffs in Axonal Scaling: Implications for Brain Function

Wang S.S.-H.
Department of Molecular Biology and Princeton Neuroscience Institute, Princeton University, Princeton, N.J., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 10/7/2008

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 0

ISSN: 0006-8977 (Print)
eISSN: 1421-9743 (Online)

For additional information: http://www.karger.com/BBE

Abstract

Like electrical wires, axons carry signals from place to place. However, unlike wires, because of the electrochemical mechanisms for generating and propagating action potentials, the performance of an axon is strongly linked to the costs of its construction and operation. As a consequence, the architecture of brain wiring is biophysically constrained to trade off speed and energetic efficiency against volume. Because the biophysics of axonal conduction is well studied, this tradeoff is amenable to quantitative analysis. In this framework, an examination of axon tract composition can yield insights into neural circuit function in regard to energetics, processing speed, spike timing precision, and average rates of neural activity.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 10/7/2008

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 0

ISSN: 0006-8977 (Print)
eISSN: 1421-9743 (Online)

For additional information: http://www.karger.com/BBE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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