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Vol. 84, No. 3-4, 1999
Issue release date: 1999
Cytogenet Cell Genet 84:230–232 (1999)

The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome 1p33→p32

Fujii J. · Hamaoka R. · Matsumoto A. · Fujii T. · Yamaguchi Y. · Egashira M. · Miyoshi O. · Niikawa N. · Taniguchi N.
aDepartment of Biochemistry, Osaka University Medical School, Osaka, and Departments of bHuman Genetics and cOrthopaedics, Nagasaki University School of Medicine, Nagasaki (Japan)

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Genomic DNA encoding for human aldehyde reductase (AKR1A1), a member of the aldo-keto reductase superfamily, was isolated and characterized. The genomic DNA is approximately 16 kb in length and contains eight exons which encode the entire coding region and the 3′-untranslated sequences. AKR1A1 was localized on chromosome 1p33→p32 by fluorescence in situ hybridization.

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