Nonorgan-Specific Autoantibodies and Immunoglobulin Allotypes in Relatives of Patients with Monoclonal GammopathyYouinou P. · Fauchier C. · Prou O. · Rivat-Peran L. · Jouquan J. · Moysan J.F. · Le Menn G.
aClinique Médicale Harvier, Centre Hospitalier Universitaire, Brest, France; bLaboratoire d’Histo-compatibilité, Centre National de Transfusion Sanguine, Paris, France; cUnite 78 Inserm, Bois-Guillaume, France
Polyclonal immunoglobulin increase, rheumatoid factor, antinuclear antibodies and cold lymphocytotoxins were detected 10, 8, 7 and 8 times, respectively, in a group of these informative families (22, 17 and 29 subjects tested, respectively). Each family included at least 1 subject with a monoclonal gammopathy in addition to that of the proband. No correlation could be shown between any of these abnormalities and Gm haplotypes. Nonetheless, it is worth noting that 6 out of 41 relatives under 30 years of age had cold lymphocytotoxins.
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