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Vol. 87, No. 1-2, 1999
Issue release date: 1999
Cytogenet Cell Genet 87:108–112 (1999)

Structure and chromosome mapping of the human SIX4 and murine Six4 genes

Ozaki H. · Yamada K. · Kobayashi M. · Asakawa S. · Minoshima S. · Shimizu N. · Kajitani M. · Kawakami K.
aDepartment of Biology, Jichi Medical School, Tochigi; bDepartment of Biosciences, Teikyo University, Tochigi; cInstitute of Basic Medical Sciences, University of Tsukuba, Tsukuba; and dDepartment of Molecular Biology, Keio University School of Medicine, Tokyo (Japan)

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Six4, a member of the homeobox gene subfamily (Six), is expressed in a developmentally regulated fashion, and supposed to be involved in embryogenesis. We cloned the human SIX4 and murine Six4 genomic DNAs and determined their structures. The structure, including the 5′ upstream region of both genes, was well conserved suggesting the conserved function and regulation of these genes. Human SIX4 was mapped to chromosome 14q23.   

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