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Table of Contents
Vol. 46, No. 3, 1996
Issue release date: 1996
Hum Hered 1996;46:136–141
(DOI:10.1159/000154342)

Molecular Characterization of Erythrocyte Glucose-6-Phosphate Dehydrogenase Deficiency in Al-Ain District, United Arab Emirates

Bayoumi R.A. · Nur-E-Kamal M.S.A. · Tadayyon M. · Mohamed K.K.A. · Mahboob B.H. · Qureshi M.M. · Lakhani M.S. · Awaad M.O. · Kaeda J. · Vulliamy T.J. · Luzzatto L.
aDepartment of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, and bDepartment of Internal Medicine, Al-Ain Hospital, Al-Ain, United Arab Emirates; cDepartment of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK

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Abstract

In a cross-sectional study, the activity, electrophoretic mobility and genotypes of glucose-6-phosphate dehydrogenase (G6PD) were determined among healthy, UAE national school boys from Al-Ain District in the United Arab Emirates. The prevalence of G6PD deficiency in this population sample was 11%. The majority of G6PD-deficient subjects were descendants of Omani, Baluchi or Yemeni migrants. Of 18 deficient subjects, 16 had an enzyme activity of < 10% of normal while 2 had an activity of just above 10%. Electrophoresis was performed on 166 samples and showed that, apart from deficient samples, all had the normal mobility of G6PD type B. Of the 18 deficient subjects, 14 had the B type mobility of G6PD Mediterranean and 4 had the A type mobility of G6PD A-. Genotyping demonstrated that 10 had the Mediterranean mutation while 3 had the A-mutation, consistent with their electrophoretic mobility. Another 3 had the G6PD Aures mutation, recently described as polymorphic in Algeria and Spain. The mutations in the remaining 2 subjects have not yet been identified.



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