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Vol. 87, No. 3-4, 1999
Issue release date: 1999
Cytogenet Cell Genet 87:265–268 (1999)
(DOI:10.1159/000015443)

Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome

Maho A. · Bensimon A. · Vassart G. · Parmentier M.
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Abstract

Abstract.

Human CC-chemokine receptor genes are known to be clustered. The detailed structure of this cluster was established by radiation hybrid mapping, and organization of BAC contigs by fluorescence hybridization on combed genomic DNA. A main cluster of six genes (CCR1, CCR3, CCRL2, CCR5, CCR2 and CCXCR1), covered by four BACs, was mapped to the 3p21.3 region of the human genome. Five other genes (CCR9, CCBP2, CX3CR1, CCR8 and CCR4) were found to be spread over a relatively large region between this main cluster and the 3p telomere.   

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References

  1. Littman DR: Chemokine receptors: keys to AIDS pathogenesis? Cell 93:677–680 (1998).
  2. Maho A, Carter A, Bensimon A, Vassart G, Parmentier M: Physical mapping of the CC-chemokine gene cluster on the human 17q11.2 region. Genomics 59: in press (1999).
  3. Mantovani A: The chemokine system: redundancy for robust outputs. Immunol Today 20:254–257 (1999).
  4. Michalet X, Ekong R, Fougerousse F, Rousseaux S, Schurra C, Hornigold N, van Slegtenhorst M, Wolfe J, Povey S, Beckmann J, Bensimon A: Dynamic molecular combing: stretching the whole human genome for high-resolution studies. Science 277:1518–1523 (1997).
  5. Mitelman F, Kaneko Y, Trent J: Report of the committee on chromosome changes in neoplasia. Cytogenet Cell Genet 58:1053–1079 (1991).
  6. Naruse K, Ueno M, Satoh T, Nomiyama H, Tei H, Takeda M, Ledbetter DH, Van Coillie E, Opdenakker G, Gunge N, Sakaki Y, Iio M, Miura RA: YAC contig of the human CC-chemokine genes clustered on chromosome 17q11.2. Genomics 34:236–240 (1996).

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  7. Samson M, Soularue P, Vassart G, Parmentier M: The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the 3p21.3→p24 region of chromosome 3. Genomics 36:522–526 (1996).
  8. Walter MA, Spillett DJ, Thomas P, Weissenbach J, Goodfellow PN: A method for consulting radiation hybrid maps of whole genomes. Nature Genet 7:22–28 (1994).
  9. Wang JM, Deng X, Gong W, Su S: Chemokines and their role in tumor growth and metastasis. J Immunol Methods 220:1–17 (1998).

    External Resources

  10. Ward SG, Westwick J: Chemokines: understanding their role in T-lymphocyte biology. Biochem J 333:457–470 (1998).
  11. Zaballos A, Gutierrez J, Varona R, Ardavin C, Marquez G: Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9 the receptor for the chemokine TECK. J Immunol 162:5671–5675 (1999).

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