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Vol. 87, No. 3-4, 1999
Issue release date: 1999
Cytogenet Cell Genet 87:265–268 (1999)

Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome

Maho A. · Bensimon A. · Vassart G. · Parmentier M.
aIRIBHN and bService de Génétique Médicale, Université Libre de Bruxelles, Campus Erasme, Brussels (Belgium); cLaboratoire de Biophysique de l’ADN, Département des Biotechnologies, Institut Pasteur, Paris (France)

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Human CC-chemokine receptor genes are known to be clustered. The detailed structure of this cluster was established by radiation hybrid mapping, and organization of BAC contigs by fluorescence hybridization on combed genomic DNA. A main cluster of six genes (CCR1, CCR3, CCRL2, CCR5, CCR2 and CCXCR1), covered by four BACs, was mapped to the 3p21.3 region of the human genome. Five other genes (CCR9, CCBP2, CX3CR1, CCR8 and CCR4) were found to be spread over a relatively large region between this main cluster and the 3p telomere.   

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