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Vol. 42, No. 5, 2008
Issue release date: September 2008
Section title: Original Paper
Caries Res 2008;42:380–386
(DOI:10.1159/000154783)

Effect of Starch and Sucrose on Dental Biofilm Formation and on Root Dentine Demineralization

Aires C.P. · Del Bel Cury A.A. · Tenuta L.M.A. · Klein M.I. · Koo H. · Duarte S. · Cury J.A.
aPiracicaba Dental School, University of Campinas, Piracicaba, Brazil; bEastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, Rochester, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/7/2008
Accepted: 7/7/2008
Published online: 9/10/2008

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 4

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: http://www.karger.com/CRE

Abstract

The cariogenicity of starch alone or in combination with sucrose is controversial and the effect on dentine demineralization and on the dental biofilm formed has not been explored under controlled conditions. A crossover, single-blind study was conducted in four steps of 14 days each, during which 11 volunteers wore palatal appliance containing 10 slabs of root dentine to which the following treatments were applied extraorally: 2% starch gel-like solution (starch group); 10% sucrose solution (sucrose group); a solution containing 2% starch and 10% sucrose (starch + sucrose group), or 2% starch solution followed by 10% sucrose solution (starch → sucrose group). On the 14th day of each phase the biofilms were collected for biochemical and microbiological analyses, and dentine demineralization was assessed by hardness. A higher demineralization was found in dentine exposed to sucrose and starch sucrose combinations than to starch alone (p < 0.01), but the sucrose-containing groups did not differ significantly from each other (p > 0.05). The concentrations of soluble and insoluble extracellular polysaccharides (EPS), and the proportion of insoluble EPS, were lower in the biofilm formed in presence of starch (p < 0.01) than in those formed in the presence of sucrose or sucrose/starch combinations; however, no significant difference was observed among the groups containing sucrose (p > 0.05). RNA was successfully isolated and purified from in situ biofilms and only biofilms formed in response to sucrose and starch/sucrose combinations showed detectable levels of gtfB and gtfC mRNA. The findings suggest that the combination of starch with sucrose may not be more cariogenic to dentine than sucrose alone.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/7/2008
Accepted: 7/7/2008
Published online: 9/10/2008

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 4

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: http://www.karger.com/CRE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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