Journal Mobile Options
Table of Contents
Vol. 89, No. 1-2, 2000
Issue release date: 2000
Cytogenet Cell Genet 89:24–28 (2000)

Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11→q12

Sohal J. · Reiter A. · Goldman J.M. · Cross N.C.P.
aDepartment of Haematology, Imperial College School of Medicine, Hammersmith Hospital, London (UK), and bIII Medizinische Universitätsklinik, Klinikum Mannheim der Universität Heidelberg, Mannheim (Germany)

Individual Users: Register with Karger Login Information

Please create your User ID & Password

Contact Information

I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in



We have cloned a novel, widely expressed human gene, ZNF237, that shows extensive similarity to the N-terminal region of ZNF198. Two alternatively spliced regions were identified by RT-PCR; the major splice variant is predicted to encode a 383 amino acid protein that contains a single diverged MYM domain. ZNF237 maps to 13q11→q12, immediately proximal to ZNF198.   

Copyright © 2000 S. Karger AG, Basel

Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.


  1. Aguiar RCT, Chase A, Coulthard S, Macdonald DHC, Carapeti M, Reiter A, Sohal J, Lennard A, Goldman JM and Cross NCP: Abnormalities of chromosome band 8p11 in leukemia: two clinical syndromes can be distinguished on the basis of MOZ involvement. Blood 90:3130–3135 (1997).
  2. Cross NCP, Melo JV, Feng L, Goldman JM: An optimized multiplex polymerase chain reaction (PCR) for detection of BCR-ABL fusion mRNAs in haematological disorders. Leukemia 8:186–189 (1994).
  3. Frohman MA: Rapid amplification of complementary DNA ends for generation of full-length complementary DNAs: thermal RACE. Methods Enzymol 218:340 (1993).
  4. Gyapay G, Schmit, K, Fizames C, Jones H, Vega-Czarny N, Spillett D, Muselet D, Prud’Homme JF, Dib C, Auffray C, Morissette J, Weissenbach J, Goodfellow PN: A radiation hybrid map of the hyman genome. Hum molec Genet 5:339–346 (1996).
  5. Kibar Z, Der Kaloustian VM, Brais B, Hani V, Fraser FC, Rouleau GA: The gene responsible for Clouston hidrotic ectodermal dysplasia maps to the pericentromeric region of chromosome 13q. Hum molec Genet 5:543–547 (1996).

    External Resources

  6. Kibar Z, Lafreniere RG, Chakravati A, Wang J-C, Chevrette M, Der Kaloustian VM, Rouleau GA: A radiation hybrid map of 48 loci including the Clouston hidrotic ectodermal dysplasia locus in the pericentromeric region of chromosome 13q. Genomics 56:127–139 (1999).

    External Resources

  7. Kozak M. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucl Acids Res 15:8125–8148 (1987).
  8. Kulkarni S, Reiter A, Smedley D, Goldman JM, Cross NCP: Genomic structure of ZNF198 and location of breakpoints in the t(8;13)(p11;q12) myeloproliferative syndrome. Genomics 55:118–121 (1999).
  9. Lynch SA, Ashcroft KA, Zwolinski S, Clarke C, Burn J: Kabuki syndrome-like features in monozygotic twin boys with a pseudodicentric chromosome 13. J med Genet 32:227–230 (1995).

    External Resources

  10. Maarel SM van der, Scholten IH, Huber I, Philippe C, Suijkerbuijk RF, Gilgenkrantz S, Kere J, Cremers FP, Ropers HH: Cloning and characterization of DXS6673E, a candidate gene for X-linked mental retardation in Xq13.1. Hum molec Genet 5:887–897 (1996).

    External Resources

  11. Macdonald D, Aguiar RCT, Mason, PJ, Goldman JM, Cross NCP: A new myeloproliferative disorder associated with chromosomal translocations involving 8p11: a review. Leukemia 9:1628–1630 (1995).

    External Resources

  12. Mackay JP, Crossley M: Zinc fingers are sticking together. Trends biochem Sci 23:1–4 (1998).
  13. Popovici C, Adelaide J, Ollendorff V, Chaffanet M, Guasch G, Jacrot M, Leroux D, Birnbaum D, Pebusque MJ: Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13). Proc natl Acad Sci, USA 95:5712–5717 (1998).
  14. Reiter A, Sohal J, Kulkarni S, Chase A, Macdonald DHC, Aguiar RCT, Goncalves C, Hernandez JM, Jennings BA, Goldman JM, Cross NCP: Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome. Blood 92:1735–1742 (1998).
  15. Richter A, Rioux RD, Bouchard J-P, Mercier J, Mathieu J, Ge B, Poirer J, Julien D, Gyapay G, Weissenbach J, Hudson TJ, Melançon SB, Morgan K: Location score and haplotype analyses of the locus for autosomal recessive spastic ataxia of Charlevoix-Saguenay in chromosome region 13q11. Am J hum Genet 64:768–775 (1999).
  16. Smedley D, Demiroglu A, Abdul-Rauf M, Heath C, Cooper C, Shipley J, Cross NCP: ZNF198-FGFR1 transforms Ba/F3 cells to factor independence and results in high level tyrosine phosphorylation of STAT 1 and STAT 5. Neoplasia 1:349– 355 (1999a).
  17. Smedley D, Hamoudi R, Clark J, Warren W, Abdul Rauf M, Somer, G, Venter D, Fagan K, Cooper C, Shipley J: The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP. Hum molec Genet 7:637–642 (1998).

    External Resources

  18. Smedley D, Hamoudi R, Yong-Jie L, Cooper C, Shipley J: Cloning and mapping of members of the MYM family. Genomics 60:244–247 (1999b).
  19. Sohal J, Chase A, Goldman JM, Cross NCP: Assignment of ZNF262 to human chromosome band 1p34→p32 by in situ hybridization. Cytogenet Cell Genet 85:306–307 (1999).
  20. Still IH, Cowell JK: The t(8;13) atypical myeloproliferative disorder: further analysis of the ZNF198 gene and lack of evidence for multiple genes disrupted on chromosome 13 [letter]. Blood 92:1456–1458 (1998).
  21. Suyama M, Nagase T, Ohara O: HUGE: a database for human large proteins identified by Kazusa cDNA sequencing project. Nucl Acids Res 27:338–339 (1999).
  22. Xiao S, Nalabolu SR, Aster JC, Ma J, Abruzzo L, Jaffe ES, Stone R, Weissman SM, Hudson TJ, Fletcher JA: FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukæmia/lymphoma syndrome. Nature Genet 18:84–87 (1998).

    External Resources

Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50