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Vol. 1, No. 5, 2008
Issue release date: October 2008
Section title: Original Article
Obes Facts 2008;1:266–273
(DOI:10.1159/000158874)

Influence of Partial Sleep Deprivation on Energy Balance and Insulin Sensitivity in Healthy Women

Bosy-Westphal A.a · Hinrichs S.a · Jauch-Chara K.b · Hitze B.a · Later W.a · Wilms B.a,b · Settler U.a · Peters A.b · Kiosz D.a · Müller M.J.a
a Institut für Humanernährung und Lebensmittelkunde, Christian-Albrechts-University Kiel, bDepartment of Internal Medicine I, University of Lübeck, Germany
email Corresponding Author

Abstract

Background: Voluntary sleep restriction is a lifestyle feature of modern societies that may contribute to obesity and diabetes. The aim of the study was to investigate the impact of partial sleep deprivation on the regulation of energy balance and insulin sensitivity. Subjects and Methods: In a controlled intervention, 14 healthy women (age 23–38 years, BMI 20.0–36.6 kg/m2) were investigated after 2 nights of >8 h sleep/night (T0), after 4 nights of consecutively increasing sleep curtailment (7 h sleep/ night, 6 h sleep/night, 6 h sleep/night and 4 h sleep/night; T1) and after 2 nights of sleep recovery (>8 h sleep/night; T2). Resting and total energy expenditure (REE, TEE), glucose-induced thermogenesis (GIT), physical activity, energy intake, glucose tolerance and endocrine parameters were assessed. Results: After a decrease in sleep du-ration, energy intake (+20%), body weight (+0.4 kg), leptin / fat mass (+29%), free triiodothyronine (+19%), free thyroxine (+10%) and GIT (+34%) significantly increased (all p < 0.05). Mean REE, physical activity, TEE, oral glucose tolerance, and ghrelin levels remained unchanged at T1. The effect of sleep loss on GIT, fT3 and fT4 levels was inversely related to fat mass. Conclusion: Short-term sleep deprivation increased energy intake and led to a net weight gain in women. The effect of sleep restriction on energy expenditure needs to be specifically addressed in future studies using reference methods for total energy expenditure.

© 2008 S. Karger AG, Basel


  

Key Words

  • Sleep deprivation
  • Energy intake
  • Energy expenditure
  • Endocrine regulation of energy balance

 Introduction


  

Author Contacts

Prof. Dr. med. Manfred J. Müller, Institut für Humanernährung und Lebensmittelkunde, Christian-Albrechts-Universität zu Kiel, Düsternbrooker Weg 17, 24105 Kiel, Germany, Tel. +49 43188056-70, Fax -79, mmueller@nutrfoodsc.uni-kiel.de

  

Article Information

Published online: October 23, 2008
Number of Print Pages : 8
Number of Figures : 4, Number of Tables : 2, Number of References : 43

  

Publication Details

Obesity Facts (The European Journal of Obesity)

Vol. 1, No. 5, Year 2008 (Cover Date: October 2008)

Journal Editor: Hebebrand J. (Essen)
ISSN: 1662–4025 (Print), eISSN: 1662–4033 (Online)

For additional information: http://www.karger.com/OFA


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Abstract

Background: Voluntary sleep restriction is a lifestyle feature of modern societies that may contribute to obesity and diabetes. The aim of the study was to investigate the impact of partial sleep deprivation on the regulation of energy balance and insulin sensitivity. Subjects and Methods: In a controlled intervention, 14 healthy women (age 23–38 years, BMI 20.0–36.6 kg/m2) were investigated after 2 nights of >8 h sleep/night (T0), after 4 nights of consecutively increasing sleep curtailment (7 h sleep/ night, 6 h sleep/night, 6 h sleep/night and 4 h sleep/night; T1) and after 2 nights of sleep recovery (>8 h sleep/night; T2). Resting and total energy expenditure (REE, TEE), glucose-induced thermogenesis (GIT), physical activity, energy intake, glucose tolerance and endocrine parameters were assessed. Results: After a decrease in sleep du-ration, energy intake (+20%), body weight (+0.4 kg), leptin / fat mass (+29%), free triiodothyronine (+19%), free thyroxine (+10%) and GIT (+34%) significantly increased (all p < 0.05). Mean REE, physical activity, TEE, oral glucose tolerance, and ghrelin levels remained unchanged at T1. The effect of sleep loss on GIT, fT3 and fT4 levels was inversely related to fat mass. Conclusion: Short-term sleep deprivation increased energy intake and led to a net weight gain in women. The effect of sleep restriction on energy expenditure needs to be specifically addressed in future studies using reference methods for total energy expenditure.

© 2008 S. Karger AG, Basel


  

Author Contacts

Prof. Dr. med. Manfred J. Müller, Institut für Humanernährung und Lebensmittelkunde, Christian-Albrechts-Universität zu Kiel, Düsternbrooker Weg 17, 24105 Kiel, Germany, Tel. +49 43188056-70, Fax -79, mmueller@nutrfoodsc.uni-kiel.de

  

Article Information

Published online: October 23, 2008
Number of Print Pages : 8
Number of Figures : 4, Number of Tables : 2, Number of References : 43

  

Publication Details

Obesity Facts (The European Journal of Obesity)

Vol. 1, No. 5, Year 2008 (Cover Date: October 2008)

Journal Editor: Hebebrand J. (Essen)
ISSN: 1662–4025 (Print), eISSN: 1662–4033 (Online)

For additional information: http://www.karger.com/OFA


Article / Publication Details

First-Page Preview
Abstract of Original Article

Published online: 10/23/2008
Issue release date: October 2008

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 1662-4025 (Print)
eISSN: 1662-4033 (Online)

For additional information: http://www.karger.com/OFA


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.