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Vol. 2, No. 4, 1999
Issue release date: June 2000
Section title: Original Paper
Community Genet 1999;2:173–178
(DOI:10.1159/000016208)

Prevalence of Pedigrees Suggestive of Hereditary Nonpolyposis Colorectal Cancer among a Community Sample of Women Eligible for Screening Mammography

Ramsey S.D. · Freedman A.N. · Berry K. · Andersen M.R. · Urban N.
aDepartment of Medicine, University of Washington, bFred Hutchinson Cancer Research Center, Seattle, Wash., cNational Cancer Institute, Rockville, Md., dDepartment of Biostatistics, University of Washington, Seattle, Wash., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 6/13/2000

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 5

ISSN: 1662-4246 (Print)
eISSN: 1662-8063 (Online)

For additional information: http://www.karger.com/PHG

Abstract

Objective: To determine from a large cohort of women eligible for screening mammography, the number who would meet criteria for genetic testing for hereditary nonpolyposis colorectal cancer (HNPCC). Methods: Detailed personal and family cancer histories, obtained from 6,682 women aged 50–80 years randomly selected from communities in Washington State, were matched to the Amsterdam criteria, Bethesda guidelines, and Japanese criteria for HNPCC. Results: One (0.015%) respondent met the Amsterdam criteria, 2 (0.035%) met the Japanese criteria and 5 (0.075%) met the Bethesda guidelines. Conclusion: Using the time of presentation for initial mammography as an opportunity to screen for HNPCC would detect very few families at high risk for this condition.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 6/13/2000

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 5

ISSN: 1662-4246 (Print)
eISSN: 1662-8063 (Online)

For additional information: http://www.karger.com/PHG


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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    External Resources

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