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Prevalence of Pedigrees Suggestive of Hereditary Nonpolyposis Colorectal Cancer among a Community Sample of Women Eligible for Screening Mammography

Ramsey S.D.a,b · Freedman A.N.c · Berry K.d · Andersen M.R.b · Urban N.b
aDepartment of Medicine, University of Washington, bFred Hutchinson Cancer Research Center, Seattle, Wash., cNational Cancer Institute, Rockville, Md., dDepartment of Biostatistics, University of Washington, Seattle, Wash., USA Community Genet 1999;2:173–178 (DOI:10.1159/000016208)


Objective: To determine from a large cohort of women eligible for screening mammography, the number who would meet criteria for genetic testing for hereditary nonpolyposis colorectal cancer (HNPCC). Methods: Detailed personal and family cancer histories, obtained from 6,682 women aged 50–80 years randomly selected from communities in Washington State, were matched to the Amsterdam criteria, Bethesda guidelines, and Japanese criteria for HNPCC. Results: One (0.015%) respondent met the Amsterdam criteria, 2 (0.035%) met the Japanese criteria and 5 (0.075%) met the Bethesda guidelines. Conclusion: Using the time of presentation for initial mammography as an opportunity to screen for HNPCC would detect very few families at high risk for this condition.

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