Pathobiology 2008;75:356–363

Susceptibility of XRCC3, XPD, and XPG Genetic Variants to Cervical Carcinoma

He X.a · Ye F.c · Zhang J.b · Cheng Q.c · Shen J.c · Chen H.c
Departments of aGynecology and bGynecologic Oncology and cWomen’s Reproductive Health Laboratory of Zhejiang Province, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
email Corresponding Author

 goto top of outline Key Words

  • Cervical carcinoma
  • Single nucleotide polymorphism
  • XRCC3
  • XPD
  • XPG

 goto top of outline Abstract

Objective: DNA repair genes play a key role in maintaining genomic stability and integrity. DNA repair gene polymorphisms, such as those of XRCC3 and xeroderma pigmentosum, complementation group D and G (XPD, XPG), contribute to carcinogenesis. In this study, we investigated the correlation between cervical carcinoma risk and XRCC3, XPD, XPG genetic variants. Methods: A case-control study of 400 cases including 200 carcinoma, 200 cervical intraepithelial neoplasia (CIN) and 200 normal women was performed. Four single nucleotide polymorphisms (SNPs) (XRCC3 Thr241Met, XPG His1104Asp, XPD Asp312Asn, and XPD Lys751Gln) were genotyped by mismatch amplification polymerase chain reaction. Results: Women carrying homozygous Asp1104Asp genotypes had a significantly decreased risk of cervical or cervical squamous cell carcinoma compared to His1104Asp or His1104His genotypes. Similarly, XPD Asn312Asn (AA) reduced the risk of cervical or cervical squamous cell carcinoma. No association of XRCC3 Thr241Met or XPD Lys751Gln and cervical carcinoma was found. None of the 4 SNPs influenced the risk of CIN in our study. Conclusion: Our results support the hypothesis that genetic variations in DNA repair genes may contribute to an inherited genetic susceptibility to cervical carcinoma.

Copyright © 2008 S. Karger AG, Basel

 goto top of outline References
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 goto top of outline Author Contacts

Huaizeng Chen
Women’s Reproductive Health Laboratory of Zhejiang Province
Women’s Hospital, School of Medicine, Zhejiang University
Xueshi Rd No. 2, Hangzhou, 310006 (China)
Tel. +86 571 8706 1501, Fax +86 571 8706 1878, E-Mail

 goto top of outline Article Information

Received: May 2, 2008
Accepted after revision: July 14, 2008
Published online: December 15, 2008
Number of Print Pages : 8
Number of Figures : 0, Number of Tables : 5, Number of References : 29

 goto top of outline Publication Details

Pathobiology (Exploring the basis of disease)

Vol. 75, No. 6, Year 2008 (Cover Date: December 2008)

Journal Editor: Borisch B. (Geneva), Yasui W. (Hiroshima)
ISSN: 1015-2008 (Print), eISSN: 1423-0291 (Online)

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