Table of Contents
To view the fulltext, log-in or choose pay-per-view options:
Get Access

Paroxysmal Non-Kinesigenic Dyskinesia Caused by the Mutation of MR-1 in a Large Polish Kindred

Friedman A.a · Zakrzewska-Pniewska B.b · Domitrz I.b · Lee H.-Y.c · Ptacek L.c · Kwiecinski H.b
aDepartment of Neurology, Faculty of Health Science, and bDepartment of Neurology, Medical Faculty, Medical University in Warsaw, Warsaw, Poland; cDepartment of Neurology, UCSF, San Francisco, Calif., USA Eur Neurol 2009;61:39–41 (DOI:10.1159/000165348)

Abstract

Paroxysmal non-kinesigenic dyskinesia (PNKD) is a clinical syndrome of sudden involuntary movements, mostly of dystonic type, which may be triggered by alcohol or coffee intake, stress and fatigue. The attacks of PNKD may consist of various combinations of dystonia, chorea, athetosis and balism. They can be partial and unilateral, but mostly the hyperkinetic movements are bilateral and generalized. We present a large Polish family with 7 symptomatic members of the family in 6 generations. In all affected persons, the onset of clinical symptoms was in early childhood. All male cases showed an increase in severity and frequency of the attacks with ageing, while the only living female patient noticed an improvement of PNKD during both her pregnancies and also after menopause. In addition, at the age of 55 years, she developed symptoms of Parkinson’s disease with good response to levodopa treatment.

 

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.


Pay-per-View Options
Direct payment This item at the regular price: USD 33.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 23.00