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A Randomized Trial of Low-Animal-Protein or High-Fiber Diets for Secondary Prevention of Calcium Nephrolithiasis

Dussol B.a, b · Iovanna C.b · Rotily M.c · Morange S.b · Leonetti F.e · Dupuy P.b · Vazi A.b · Saveanu A.a · Loundou A.d · Berland Y.a, b
aCentre de Néphrologie et de Transplantation Rénale, Assistance Publique, Hôpitaux de Marseille, Université Aix-Marseille II, bCentre d’Investigations Cliniques, Assistance Publique, Hôpitaux de Marseille et INSERM, cORS PACA-INSERM U379, et dUnité d’Aide Méthodologique, Université Aix-Marseille II, Marseille, et eService de Néphrologie, CHG Saint Brieuc, Saint-Brieuc, France Nephron Clin Pract 2008;110:c185 (DOI:10.1159/000167271)


Background: The purpose of this trial was to evaluate the efficacy of a low-animal-protein diet (LAPD) or a high-fiber diet (HFD) for the prevention of calcium nephrolithiasis recurrence. Methods: We conducted a 4-year randomized trial comparing the effect of 2 diets in 175 idiopathic calcium stone formers. Fifty-five were assigned to a LAPD (<13% of total energy derived from protein), 60 were assigned to a HFD (>25 g/day fiber) and 60 were placed on a normal diet (control group). The primary outcome measure was the time to the first recurrence of calcium nephrolithiasis. Daily urine compositions were analyzed at baseline, at month 4 (M4), M12, M24, M36 and M48. Results: Seventy-three patients completed the trial (23 in the LAPD group, 27 in the HFD group and 23 in the control group). Recurrence was 48% (11/23) in the LAPD group, 63% (17/27) in the HFD group and 48% (11/23) in the control group (p = not significant). During follow-up, urinary calcium levels and other urine parameters did not change significantly in the 3 groups, except for a significant decrease in 24-hour urinary sulfate in the LAPD group. Conclusions: In idiopathic calcium stone formers, neither a LAPD nor a HFD appeared to provide protection against recurrence.


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