Table of Contents
To view the fulltext, log-in or choose pay-per-view options:
Get Access

Serum Uric Acid and Endothelial Dysfunction in Continuous Ambulatory Peritoneal Dialysis Patients

Tang Z.a · Cheng L.-T.a · Li H.-Y.a, b · Wang T.a
aDivision of Nephrology, Peking University Third Hospital, Beijing, and bDivision of Nephrology, Zhengzhou University First Affiliated Hospital, Zhengzhou, China Am J Nephrol 2009;29:368–373 (DOI:10.1159/000168484)


Background: Endothelial dysfunction is an early predictor of cardiovascular events. Hyperuricemia has been shown to be associated with increased cardiovascular mortality. It remains unclear if serum uric acid (UA) is associated with endothelial dysfunction in peritoneal dialysis patients. Methods: In this cross-sectional study, the relationship of UA and endothelial dysfunction was investigated in 189 stable peritoneal dialysis patients. The clinical and laboratory data were collected. Endothelial function was estimated by flow-mediated dilatation (FMD) of the brachial artery and expressed as percentage change relative to baseline diameter. Results: UA levels did not differ between 93 male and 96 female patients (416.31 ± 86.93 vs. 395.52 ± 87.47 μmol/l, p > 0.05). Patients were grouped into three tertiles on the basis of their serum UA levels. Systolic blood pressure (p = 0.007), serum phosphate (p = 0.005), high-sensitive C-reactive protein (hs-CRP) (p < 0.001), and FMD (p = 0.016) were all different among UA tertiles. FMD was found to be related with UA (p = 0.002) and hs-CRP (p = 0.006) in a Pearson’s correlation analysis. Multivariate regression analysis showed that only UA was an independent determinant of FMD (β = –0.237, p = 0.036). Conclusion: There was an independent correlation between UA and FMD, and a higher UA level was related to worse endothelial function which may contribute to hypertension and cardiovascular morbidity.


Individual Users: Register with Karger Login Information

Please create your User ID & Password

Contact Information

I have read the Karger Terms and Conditions and agree.

Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50