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Vol. 15, No. 5, 1995
Issue release date: 1995
Am J Nephrol 1995;15:386–391

Clinical and Immune Aspects of Idiopathic Acute Tubulointerstitial Nephritis and Uveitis Syndrome

Rodriguez-Perez J.C. · Cruz-Alamo M. · Perez-Aciego P. · Macía-Heras M. · Naranjo-Hemandez A. · Plaza-Toledano C. · Hortal-Cascon L. · Fernandez-Rodriguez A.
aNephrology Service; bImmunology Unit, Hematology Department, and cRheumatology Unit, Hospital Ntra Sra del Pino, Las Palmas de Gran Canaria, Spain

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Five patients with idiopathic interstitial nephritis and uveitis without bone marrow granulomas were followed-up for 1 year. Ophthalmological examination revealed bilateral anterior uveitis. Light microscopy of the renal tissue revealed predominant lymphocyte infiltration of the interstitium. Immunohistochemical analysis revealed a clear predominance of memory T lymphocytes (CD45RO+) in the interstitial and tubular infiltration. HLA typing, and immunophenotypic studies of peripheral blood mononuclear cells including absolute lymphocyte and monocyte counts were assessed. The patients’ peripheral T-cell subpopulation did not significantly differ from control studies. With steroid treatment maintained during a period of 6-9 months renal function and uveitis responded dramatically in all patients. After 1-year follow-up, only 1 patient showed a relapse of uveitis, but there was complete clinical recovery of the nephritis in all 5 patients. The aim of this study was to describe the 1-year follow-up of 5 new cases of acute tubulointerstitial nephritis and uveitis syndrome, and assess some aspects of their cellular immunity.

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