Clinical and Immune Aspects of Idiopathic Acute Tubulointerstitial Nephritis and Uveitis SyndromeRodriguez-Perez J.C. · Cruz-Alamo M. · Perez-Aciego P. · Macía-Heras M. · Naranjo-Hemandez A. · Plaza-Toledano C. · Hortal-Cascon L. · Fernandez-Rodriguez A.
aNephrology Service; bImmunology Unit, Hematology Department, and cRheumatology Unit, Hospital Ntra Sra del Pino, Las Palmas de Gran Canaria, Spain
Five patients with idiopathic interstitial nephritis and uveitis without bone marrow granulomas were followed-up for 1 year. Ophthalmological examination revealed bilateral anterior uveitis. Light microscopy of the renal tissue revealed predominant lymphocyte infiltration of the interstitium. Immunohistochemical analysis revealed a clear predominance of memory T lymphocytes (CD45RO+) in the interstitial and tubular infiltration. HLA typing, and immunophenotypic studies of peripheral blood mononuclear cells including absolute lymphocyte and monocyte counts were assessed. The patients’ peripheral T-cell subpopulation did not significantly differ from control studies. With steroid treatment maintained during a period of 6-9 months renal function and uveitis responded dramatically in all patients. After 1-year follow-up, only 1 patient showed a relapse of uveitis, but there was complete clinical recovery of the nephritis in all 5 patients. The aim of this study was to describe the 1-year follow-up of 5 new cases of acute tubulointerstitial nephritis and uveitis syndrome, and assess some aspects of their cellular immunity.
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