Journal Mobile Options
Table of Contents
Vol. 24, No. 4, 2008
Issue release date: January 2009
Fetal Diagn Ther 2008;24:425–428

A New and Practical Aspartate Aminotransferase Test in Vaginal Washing Fluid for the Detection of Preterm Premature Rupture of Membranes

Kale E. · Kuyumcuoğlu U. · Kale A. · Güzel A.İ. · Canoruc N.
Departments of aClinical Biochemistry and bObstetrics and Gynecology, Dicle University School of Medicine, Diyarbakir, Turkey

Individual Users: Register with Karger Login Information

Please create your User ID & Password

Contact Information

I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in


Objectives: To determine whether measurement of aspartate aminotransferase (Ast) and alanine aminotransferase (Alt) levels in vaginal fluid is useful for the diagnosis of preterm premature rupture of membranes (PPROM). Study Design: The PPROM group and normal pregnancy group consisted of 36 and 48 pregnant patients between 26 and 36 weeks’ gestation, respectively. Vaginal fluid Ast and Alt levels were measured in both groups. Results: Vaginal fluid Alt level was not statistically significant in the PPROM group as compared with the control group (p = 0.064). Vaginal Ast level was statistically significant in the PPROM (14.4 ± 17.46 U/l) group as compared with the control group (3.08 ± 7.8 U/l; p = 0.001). The optimal cutoff value of 3 IU/l for Ast gave a sensitivity level of 91% at a specificity of 83%, with positive and negative predictive values of 80 and 93%, respectively. Conclusion: Ast measurement from vaginal washing fluid appears to be a useful marker for the detection of PPROM.

Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.


  1. Marowitz A, Jordan R: Midwifery management of prelabor rupture of membranes at term. Midwifery Womens Health 2007;52:199–206.
  2. Helmer H: Continuing challenges in treating preterm labour: preterm prelabour rupture of the membranes. BJOG 2006;113:111–112.
  3. Cunnigham FG, Gant NF: Willliams Obstetrics. New York, McGraw-Hill, 2001, pp 707–708.
  4. Esim E, Turan C, Unal O, Dansuk R, Cengizoglu B: Diagnosis of premature rupture of membranes by identification of beta-HCG in vaginal washing fluid. Eur J Obstet Gynecol Reprod Biol 2003;107:37–40.
  5. Akercan F, Cirpan T, Kazandi M, Terek MC, Mgoyi L, Ozkinay E: The value of the insulin-like growth factor binding protein-1 in the cervical-vaginal secretion detected by immunochromatographic dipstick test in the prediction of delivery in women with clinically unconfirmed preterm premature rupture of membranes. Eur J Obstet Gynecol Reprod Biol 2005;121:159–163.
  6. Shaarawy M, El-Minawi AM: Prolactin and calcitropic hormones in preterm premature rupture of membranes. Int J Gynaecol Obstet 2004;84:200–207.
  7. Cunningham FG, Gant NF, et al: Williams Obstetrics. New York, McGraw-Hill, 2001, p 148.
  8. Kuczynska-Sicinska J, Wojcicka-Jagodzinska J, Romejko E, Smolarczyk R, Siekierski BP, Chodzinska B: Biochemical studies of the amniotic fluid in arterial hypertension in relation to intrauterine growth retardation. I. Parameters of the proteins, lipids, enzymes and renal maturity. Ginekol Pol 1989;60:266–270.
  9. Smolarczyk R, Wojcicka-Jagodzinska J, Romejko E, Czajkowski K, Piekarski P, Teliga-Czajkowska J, Kuczynska-Sicinska J: Evaluation of fetal condition in pregnancy complicated by hypertension – biochemical assessment of amniotic fluid. II. Enzymes. Ginekol Pol 1996;67:598–602.
  10. Muller F, Dommergues M, Ville Y, Lewin F, Delvalez-Morichon N, Nihoul-Fekete C, Bargy F, Dumez Y, Boue A: Amniotic fluid digestive enzymes: diagnostic value in fetal gastrointestinal obstructions. Prenat Diagn 1994;14:973–979.
  11. Fauza D: Amniotic fluid and placental stem cells. Best Pract Res Clin Obstet Gynaecol 2004;18:877–891.

Pay-per-View Options
Direct payment This item at the regular price: USD 33.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 23.00