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Vol. 3, No. 6, 2008
Issue release date: December 2008
Free Access
Breast Care 2008;3:423–425
(DOI:10.1159/000170185)

Presence of Basement Membrane Material around the Tubules of Tubulolobular Carcinoma

Cserni G.
Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary
email Corresponding Author

Abstract

Background: Core needle biopsies represent only a small portion of a breast lesion. Rare lesions with overlapping features may be underestimated in such small samples. Case Report: A 67-year-old female underwent core needle biopsy of a 27-mm breast tumour demonstrating infiltrative glands without significant desmoplasia. Periglandular collagen IV immunostaining and the small glands were reminiscent of microglandular adenosis, and despite the infiltrative look of the microglands, the lesion was interpreted as suspicious for malignancy. Finally, the tumour proved to be a tubulolobular carcinoma. Conclusions: The tubules of tubulolobular carcinoma may show a basement membrane-like staining pattern with collagen IV, and this must be considered in the differential diagnosis of mammary lesions with small glandular architecture.


 Outline


 goto top of outline Key Words

  • Basement membrane
  • Breast cancer
  • Collagen IV
  • Tubulolobular carcinoma

 goto top of outline Summary

Background: Core needle biopsies represent only a small portion of a breast lesion. Rare lesions with overlapping features may be underestimated in such small samples. Case Report: A 67-year-old female underwent core needle biopsy of a 27-mm breast tumour demonstrating infiltrative glands without significant desmoplasia. Periglandular collagen IV immunostaining and the small glands were reminiscent of microglandular adenosis, and despite the infiltrative look of the microglands, the lesion was interpreted as suspicious for malignancy. Finally, the tumour proved to be a tubulolobular carcinoma. Conclusions: The tubules of tubulolobular carcinoma may show a basement membrane-like staining pattern with collagen IV, and this must be considered in the differential diagnosis of mammary lesions with small glandular architecture.

Copyright © 2008 S. Karger AG, Basel


goto top of outline Introduction


 goto top of outline Author Contacts

Gábor Cserni, MD, PhD, DSc, Bács-Kiskun County Teaching Hospital, Nyiri ut 38, 6000 Kecskemét, Hungary, Tel./Fax +36 76 516768, cserni@freemail.hu


 goto top of outline Article Information

Published online: November 25, 2008
Number of Print Pages : 3
Number of Figures : 3, Number of Tables : 0, Number of References : 18


 goto top of outline Publication Details

Breast Care (Multidisciplinary Journal for Research, Diagnosis and Therapy)

Vol. 3, No. 6, Year 2008 (Cover Date: December 2008)

Journal Editor: Harbeck N. (München), Jakesz R. (Wien), Thomssen C. (Halle/Saale)
ISSN: 1661–3791 (Print), eISSN: 1661–3805 (Online)

For additional information: http://www.karger.com/BRC


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Abstract

Background: Core needle biopsies represent only a small portion of a breast lesion. Rare lesions with overlapping features may be underestimated in such small samples. Case Report: A 67-year-old female underwent core needle biopsy of a 27-mm breast tumour demonstrating infiltrative glands without significant desmoplasia. Periglandular collagen IV immunostaining and the small glands were reminiscent of microglandular adenosis, and despite the infiltrative look of the microglands, the lesion was interpreted as suspicious for malignancy. Finally, the tumour proved to be a tubulolobular carcinoma. Conclusions: The tubules of tubulolobular carcinoma may show a basement membrane-like staining pattern with collagen IV, and this must be considered in the differential diagnosis of mammary lesions with small glandular architecture.



 goto top of outline Author Contacts

Gábor Cserni, MD, PhD, DSc, Bács-Kiskun County Teaching Hospital, Nyiri ut 38, 6000 Kecskemét, Hungary, Tel./Fax +36 76 516768, cserni@freemail.hu


 goto top of outline Article Information

Published online: November 25, 2008
Number of Print Pages : 3
Number of Figures : 3, Number of Tables : 0, Number of References : 18


 goto top of outline Publication Details

Breast Care (Multidisciplinary Journal for Research, Diagnosis and Therapy)

Vol. 3, No. 6, Year 2008 (Cover Date: December 2008)

Journal Editor: Harbeck N. (München), Jakesz R. (Wien), Thomssen C. (Halle/Saale)
ISSN: 1661–3791 (Print), eISSN: 1661–3805 (Online)

For additional information: http://www.karger.com/BRC


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.