Table of Contents
To view the fulltext, log-in or choose pay-per-view options:
Get Access

Determinants of Quantitative Spectral Electroencephalography in Early Alzheimer’s Disease: Cognitive Function, Regional Cerebral Blood Flow, and Computed Tomography

Claus J.J.a,b · Ongerboer de Visser B.W.b · Bour L.J.b · Walstra G.J.M.a · Hijdra A.a · Verbeeten Jr. B.c · van Royen E.A.d · Kwa V.I.H.a · van Gool W.A.a
aDepartment of Neurology, bDivision of Clinical Neurophysiology, Departments of cRadiology and dNuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands Dement Geriatr Cogn Disord 2000;11:81–89 (DOI:10.1159/000017219)


Electroencephalography (EEG) bands may have different clinical or physiological correlates at initial diagnosis of Alzheimer’s disease (AD). We studied 163 consecutive patients with probable (n = 105) and possible (n = 58) AD with measurements of cognitive function (CAMCOG), regional cerebral blood flow (rCBF) with single photon emission computed tomography using technetium-99m-labeled hexamethylpropylene amine oxime, and computed tomography (CT). Lower CAMCOG scores were significantly and most strongly associated with lower parieto-occipital and fronto-central alpha power. In a separate analysis of cognitive domains, disturbances in language, praxis, attention, and abstraction were also significantly and most consistently related to decrease in alpha power. Presence of cortical atrophy as measured on CT showed some statistically significant relations with EEG bands, but these associations were not consistent. Lower temporal and parietal rCBF were significantly related to lower parieto-occipital alpha activity. Presence of leukoaraiosis was significantly associated with lower beta values, but also with higher absolute theta and delta activity. The results suggest that alpha on EEG is most closely linked to cognitive function and rCBF, while beta and theta activity more likely reflect lower cortical or subcortical changes. Our study thus provides evidence that the EEG bands reflect differential pathophysiologic changes in AD.

Copyright © 2000 S. Karger AG, Basel


Individual Users: Register with Karger Login Information

Please create your User ID & Password

Contact Information

I have read the Karger Terms and Conditions and agree.

Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50