Cover

Advances in the Management of Testosterone Deficiency

Editor(s): Jones T.H. (Barnsley/Sheffield) 
Table of Contents
Vol. 37, No. , 2009
Section title: Paper
Jones, T.H. (Barnsley/Sheffield) (eds): Advances in the Management of Testosterone Deficiency. Front Horm Res. Basel, Karger, 2009, vol 37, pp 91-107
(DOI:10.1159/000176047)

Testosterone and Coronary Artery Disease

Nettleship J. · Jones R. · Channer K. · Jones T.
aAcademic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, bDepartment of Cardiology, Royal Hallamshire Hospital, and cBiomedical Research Centre, Sheffield Hallam University, Sheffield, and dRobert Hague Centre for Diabetes and Endocrinology, Barnsley Hospital NHS Foundation Trust, Barnsley, UK

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/17/2008
Cover Date: 2009

Number of Print Pages: 17
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8622-1 (Print)
eISBN: 978-3-8055-8623-8 (Online)

Abstract

The strongest independent risk factors for coronary artery disease (CAD) are increasing age and male gender. Whilst a wide variation in CAD mortality exists between countries, a male to female ratio of approximately 2:1 is consistently observed. These observations have led to the assumption that testosterone may exert a detrimental influence on the cardiovascular system. Despite this, coronary atherosclerosis increases with age, whilst a marked fall in serum bioavailable testosterone levels is observed. Similarly, low testosterone levels are also associated with other cardiovascular risk factors and increased expression of mediators of the atherosclerotic process. This in itself suggests that testosterone does not promote atheroma formation. Moreover, epidemiological studies show an inverse relationship between testosterone levels and surrogate markers of atherosclerosis, which suggests that it may be a testosterone deficient state, rather than male sex which is associated with CAD. In cholesterol-fed animal models, atherosclerosis is accelerated by castration and reduced after testosterone replacement therapy. Testosterone has also been shown to improve myocardial ischemia in men with angina pectoris. Consequently, increasing evidence suggests that the process of atherosclerosis is beneficially modulated by testosterone. These studies are the focus of this chapter.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/17/2008
Cover Date: 2009

Number of Print Pages: 17
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8622-1 (Print)
eISBN: 978-3-8055-8623-8 (Online)


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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