Cover

Advances in the Management of Testosterone Deficiency

Editor(s): Jones T.H. (Barnsley/Sheffield) 
Table of Contents
Vol. 37, No. , 2009
Section title: Paper
Jones, T.H. (Barnsley/Sheffield) (eds): Advances in the Management of Testosterone Deficiency. Front Horm Res. Basel, Karger, 2009, vol 37, pp 150-162
(DOI:10.1159/000176051)

Testosterone Effects on Cognition in Health and Disease

Cherrier M.
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and Veterans Administration Puget Sound Health Care System S-182 GRECC, Seattle, Wash., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/17/2008
Cover Date: 2009

Number of Print Pages: 13
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8622-1 (Print)
eISBN: 978-3-8055-8623-8 (Online)

Abstract

Low testosterone is associated with many physical complaints as well as cognitive complaints. This article reviews the neurobiologic connection between gonadal steroids and cognitive functions, and mechanisms by which T may be considered neuroprotective. Studies of hormone replacement therapy in hypogonadal men as well as older men with late-onset hypogonadism (LOH) are reviewed as well as epidemiological studies of endogenous hormones and cognition. Studies examining T treatment in men with memory disorders such as Alzheimer’s disease (AD) will also be reviewed. Some but not all studies of androgen replacement therapy in hypogonadal younger men, older men with LOH and AD patients suggest a potential beneficial effect on cognition, however a recent study indicated a negative effect. Most studies to date have been small and need further replication with randomized controlled studies using larger sample sizes with specific consideration of treatment risk factors.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/17/2008
Cover Date: 2009

Number of Print Pages: 13
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8622-1 (Print)
eISBN: 978-3-8055-8623-8 (Online)


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.