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Vol. 120, No. 3, 2008
Issue release date: January 2009
Acta Haematol 2008;120:150–152

Primary Penile Diffuse Large B Cell Lymphoma Treated by Local Excision Followed by Rituximab-Containing Chemotherapy

Kim H.Y. · Oh S.Y. · Lee S. · Lee D.M. · Kim S.-H. · Kwon H.-C. · Hong S.H. · Yoon J.H. · Kim H.-J.
Departments of aInternal Medicine, bPathology and cUrology, Dong-A University College of Medicine, Busan, Korea

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Primary penile lymphoma is rarely observed in cases of extranodal malignant lymphoma. Owing principally to its rarity, no definite treatment modality has been established. We report the case of a 42-year-old man who presented with hematuria and a painless palpable mass on the penis which had persisted for 2 months. A 1.5 × 1.4 cm round mass was detected in the shaft of the penis. Histopathological examination of the excisional biopsy revealed CD20+ diffuse large B cell lymphoma. The patient was classified as having a stage IAE lymphoma. Because radiation often causes considerable early morbidity and later loss of function of the penis, 6 cycles of combination chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisolone) with rituximab were administered at 3-week intervals. After treatment, the patient showed a complete response and has maintained this status for the past 7 months. Multiple options, such as surgical amputation, radiotherapy and chemotherapy, are available for treatment of this condition. However, in order to minimize treatment-related morbidity and to maintain quality of life after treatment, combination chemotherapy including rituximab could be considered the treatment of choice after local excision.

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  1. Carter RD, Smith R, Alpern HD, Healey BM: Primary lymphoma of the penis with rationale of treatment. Int Urol Nephrol 1992;24:521–525.
  2. Dehner LP, Smith BH: Soft tissue tumors of the penis. A clinicopathologic study of 46 cases. Cancer 1970;25:1431–1447.
  3. Fairfax CA, Hammer CJ 3rd, Dana BW, Hanifin JM, Barry JM: Primary penile lymphoma presenting as a penile ulcer. J Urol 1995;153:1051–1052.
  4. Gonzalez-Campora R, Nogales FF Jr, Lerma E, Navarro A, Matilla A: Lymphoma of the penis. J Urol 1981;126:270–271.
  5. Gough J: Primary reticulum cell sarcoma of the penis. Br J Urol 1970;42:336–339.
  6. Koyama M, Uejima K, Konishi T, Ishida M, Kato M, Nishigaki M, Mizutani H, Matsumoto K, Kawase M, Tamaki T: A case of malignant lymphoma accompanied by Klinefelter’s syndrome. Intern Med 1992;31:496– 499.
  7. Litton M, Bergeron C: Primary lymphoma of the penis (in French). J Urol (Paris) 1987;93:99–101.
  8. Marks D, Crosthwaite A, Varigos G, Ellis D, Morstyn G: Therapy of primary diffuse large cell lymphoma of the penis with preservation of function. J Urol 1988;139:1057–1058.
  9. Oomura J, Ookita K, Takenaka M, Yamada S: Primary reticulosarcoma of the penis. Report of a case (in Japanese). Hinyokika Kiyo 1962;8:536–542.
  10. Sanz Jaka JP, Mendivil Dacal J, Ruiz I, Gomez M, Estebanez J, Martinez de Lizarduy JL, Arocena Lanz F: Verrucous carcinoma of the penis (in Spanish). Actas Urol Esp 1988;12:163–167.
  11. Stewart AL, Grieve RJ, Banerjee SS: Primary lymphoma of the penis. Eur J Surg Oncol 1985;11:179–181.
  12. Terao T, Fujii Y, Ikeda I, Masuda M, Hirokawa M, Iwabuchi K, Maeda T, Asakura S: Retroperitoneal malignant lymphoma showing follicular type: report of a case (in Japanese). Hinyokika Kiyo 1992;38:1151–1155.
  13. Watanabe K, Kurizaki Y, Ogawa A, Ishii K, Kawakami H: Primary malignant lymphoma of the penis: a case report. Int J Urol 1994;1:283–284.
  14. Yu GS, Nseyo UO, Carson JW: Primary penile lymphoma in a patient with Peyronie’s disease. J Urol 1989;142:1076–1077.

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