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Vol. 120, No. 3, 2008
Issue release date: January 2009
Section title: Case Report
Acta Haematol 2008;120:150–152
(DOI:10.1159/000178146)

Primary Penile Diffuse Large B Cell Lymphoma Treated by Local Excision Followed by Rituximab-Containing Chemotherapy

Kim H.Y. · Oh S.Y. · Lee S. · Lee D.M. · Kim S.-H. · Kwon H.-C. · Hong S.H. · Yoon J.H. · Kim H.-J.
Departments of aInternal Medicine, bPathology and cUrology, Dong-A University College of Medicine, Busan, Korea

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Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 5/26/2008
Accepted: 6/25/2008
Published online: 11/28/2008

Number of Print Pages: 3
Number of Figures: 2
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

Primary penile lymphoma is rarely observed in cases of extranodal malignant lymphoma. Owing principally to its rarity, no definite treatment modality has been established. We report the case of a 42-year-old man who presented with hematuria and a painless palpable mass on the penis which had persisted for 2 months. A 1.5 × 1.4 cm round mass was detected in the shaft of the penis. Histopathological examination of the excisional biopsy revealed CD20+ diffuse large B cell lymphoma. The patient was classified as having a stage IAE lymphoma. Because radiation often causes considerable early morbidity and later loss of function of the penis, 6 cycles of combination chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisolone) with rituximab were administered at 3-week intervals. After treatment, the patient showed a complete response and has maintained this status for the past 7 months. Multiple options, such as surgical amputation, radiotherapy and chemotherapy, are available for treatment of this condition. However, in order to minimize treatment-related morbidity and to maintain quality of life after treatment, combination chemotherapy including rituximab could be considered the treatment of choice after local excision.


Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 5/26/2008
Accepted: 6/25/2008
Published online: 11/28/2008

Number of Print Pages: 3
Number of Figures: 2
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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