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Vol. 71, No. 1, 2009
Issue release date: December 2008
ORL 2009;71:50–55

Nasal Saline Irrigation Facilitates Control of Allergic Rhinitis by Topical Steroid in Children

Li H. · Sha Q. · Zuo K. · Jiang H. · Cheng L. · Shi J. · Xu G.
aDepartment of Otolaryngology, First Affiliated Hospital of Nanjing Medical University, Nanjing, bAllergy and Immunology Research Center and Department of Immunology, Anhui Medical University, Hefei, and cOtorhinolaryngology Hospital, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China

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Objective: This study was designed to determine whether nasal saline irrigation improved the symptoms and signs of allergic rhinitis (AR) and whether nasal saline irrigation could be used as a complementary management of AR in children while less steroids were used. Method: 26 children with AR were divided into three groups and were given nasal saline irrigation and/or topical steroid. Symptoms and signs of AR and mucociliary clearance (MCC) were evaluated, and concentration of soluble intercellular adhesion molecule (sICAM)-1 in nasal secretion was detected. Results: In AR children treated with nasal irrigation and tapered topical steroid at week 8 and week 12, a significant improvement in symptoms and signs was observed, and a significant decrease in the mean values of MCC and the mean concentrations of sICAM-1 in nasal secretions was also detected. Conclusion: Nasal saline irrigation can be viewed as a good adjunctive treatment option for AR. It permitted the use of less topical steroids for controlling AR in children, which will contribute to fewer side effects and less economic burden.

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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