Journal Mobile Options
Table of Contents
Vol. 71, No. 1, 2009
Issue release date: December 2008
Section title: Original Paper
ORL 2009;71:50–55
(DOI:10.1159/000178165)

Nasal Saline Irrigation Facilitates Control of Allergic Rhinitis by Topical Steroid in Children

Li H. · Sha Q. · Zuo K. · Jiang H. · Cheng L. · Shi J. · Xu G.
aDepartment of Otolaryngology, First Affiliated Hospital of Nanjing Medical University, Nanjing, bAllergy and Immunology Research Center and Department of Immunology, Anhui Medical University, Hefei, and cOtorhinolaryngology Hospital, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restriction apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/5/2008
Accepted: 6/26/2008
Published online: 12/1/2008

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 1

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL

Abstract

Objective: This study was designed to determine whether nasal saline irrigation improved the symptoms and signs of allergic rhinitis (AR) and whether nasal saline irrigation could be used as a complementary management of AR in children while less steroids were used. Method: 26 children with AR were divided into three groups and were given nasal saline irrigation and/or topical steroid. Symptoms and signs of AR and mucociliary clearance (MCC) were evaluated, and concentration of soluble intercellular adhesion molecule (sICAM)-1 in nasal secretion was detected. Results: In AR children treated with nasal irrigation and tapered topical steroid at week 8 and week 12, a significant improvement in symptoms and signs was observed, and a significant decrease in the mean values of MCC and the mean concentrations of sICAM-1 in nasal secretions was also detected. Conclusion: Nasal saline irrigation can be viewed as a good adjunctive treatment option for AR. It permitted the use of less topical steroids for controlling AR in children, which will contribute to fewer side effects and less economic burden.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/5/2008
Accepted: 6/26/2008
Published online: 12/1/2008

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 1

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Scadding GK: Corticosteroids in the treatment of pediatric allergic rhinitis.J Allergy Clin Immunol 2001;108:S59–S64.
  2. Rabago D, Pasic T, Zgierska A, Mundt M, Barrett B, Maberry R: The efficacy of hypertonic saline nasal irrigation for chronic sinonasal symptoms. Otolaryngol Head Neck Surg 2005;133:3–8.
  3. Heatley DG, McConnell KE, Kille TL, Leverson GE: Nasal irrigation for the alleviation of sinonasal symptoms. Otolaryngol Head Neck Surg 2001;125:44–48.
  4. Garavello W, Romagnoli M, Sordo L, Gaini RM, Di Berardino C, Angrisano A: Hypersaline nasal irrigation in children with symptomatic seasonal allergic rhinitis: a randomized study. Pediatr Allergy Immunol 2003;14:140–143.
  5. Brown CL, Graham SM: Nasal irrigations: good or bad? Curr Opin Otolaryngol Head Neck Surg 2004;12:9–13.
  6. Ciprandi G, Ricca V, Passalacqua G, Fasolo A, Canonica GW: Intranasal fluticasone propionate reduces ICAM-1 on nasal epithelial cells both during early and late phase after allergen challenge. Clin Exp Allergy 1998;28:293–299.
  7. Mion O, de Mello JF Jr, Lessa MM, Goto EY, Miniti A: The role of rhinitis in chronic otitis media. Otolaryngol Head Neck Surg 2003;128:27–31.
  8. Inanli S, Oztürk O, Korkmaz M, Tutkun A, Batman C: The effects of topical agents of fluticasone propionate, oxymetazoline, and 3 and 0.9% sodium chloride solutions on mucociliary clearance in the therapy of acute bacterial rhinosinusitis in vivo. Laryngoscope 2002;112:320–325.
  9. Winther B, Arruda E, Witek TJ, Marlin SD, Tsianco MM, Innes DJ, Hayden FG: Expression of ICAM-1 in nasal epithelium and levels of soluble ICAM-1 in nasal lavage fluid during human experimental rhinovirus infection. Arch Otolaryngol Head Neck Surg 2002;128:131–136.
  10. Yilmaz T, Kurtaran H, Karadag A, Uras N: Nasal saline for allergic rhinitis: an alternative treatment method. Acta Otolaryngol (Stockh) 2004;124:1240.
  11. Garavello W, Di Berardino F, Romagnoli M, Sambataro G, Gaini RM: Nasal rinsing with hypertonic solution: an adjunctive treatment for pediatric seasonal allergic rhinoconjunctivitis. Int Arch Allergy Immunol 2005;137:310–314.
  12. Georgitis JW: Nasal hyperthermia and simple irrigation for perennial rhinitis. Changes in inflammatory mediators. Chest 1994;106:1487–1492.
  13. Di Lorenzo G, Drago A, Esposito Pellitteri M, Candore G, Colombo A, Gervasi F, Pacor ML, Purello D’Ambrosio F, Caruso C: Measurement of inflammatory mediators of mast cells and eosinophils in native nasal lavage fluid in nasal polyposis. Int Arch Allergy Immunol 2001;125:164–175.
  14. Talbot AR, Herr TM, Parsons DS: Mucociliary clearance and buffered hypertonic saline solution. Laryngoscope 1997;107:500–503.
  15. Wabnitz DA, Wormald PJ: A blinded, randomized, controlled study on the effect of buffered 0.9 and 3% sodium chloride intranasal sprays on ciliary beat frequency. Laryngoscope 2005;115:803–805.
  16. Boek WM, Keleş N, Graamans K, Huizing EH: Physiologic and hypertonic saline solutions impair ciliary activity in vitro. Laryngoscope 1999;109:396–399.
  17. Bousquet J, Van Cauwenberge P, Khaltaev N: Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001;108:S147–S334.
  18. Benninger MS, Ahmad N, Marple BF: The safety of intranasal steroids. Otolaryngol Head Neck Surg2003;129:739–750.
  19. Skoner DP, Rachelefsky GS, Meltzer EO, Chervinsky P, Morris RM, Seltzer JM, Storms WW, Wood RA: Detection of growth suppression in children during treatment with intranasal beclomethasone dipropionate. Pediatrics 2000;105:E23.
  20. Trangsrud AJ, Whitaker AL, Small RE: Intranasal corticosteroids for allergic rhinitis. Pharmacotherapy2002;22:1458–1467.
  21. Ciprandi G, Buscaglia S, Pesce G, Pronzato C, Ricca V, Parmiani S, Bagnasco M, Canonica GW: Minimal persistent inflammation is present at mucosal level in patients with asymptomatic rhinitis and mite allergy. J Allergy Clin Immunol 1995;96:971–979.
  22. Ohashi Y, Nakai Y, Tanaka A, Kakinoki Y, Ohno Y, Masamoto T, Sakamoto H, Kato A, Washio Y, Hayashi M: Soluble intercellular adhesion molecule-1 level in sera is elevated in perennial allergic rhinitis. Laryngoscope 1997;107:932–935.
  23. Gorska-Ciebiada M, Ciebiada M, Gorska MM, Gorski P, Grzelewska-Rzymowska I: Intercellular adhesion molecule 1 and tumor necrosis factor alpha in asthma and persistent allergic rhinitis: relationship with disease severity. Ann Allergy Asthma Immunol 2006;97:66–72.
  24. Ciprandi G, Catrullo A, Cerqueti P, Tosca M, Fiorino N, Canonica GW: Loratadine reduces the expression of ICAM-1. Allergy 1998;53:545–546.
  25. Benninger MS, Hadley JA, Osguthorpe JD, Marple BF, Leopold DA, Derebery MJ, Hannley ML: Techniques of intranasal steroid use. Otolaryngol Head Neck Surg 2004;130:5–24.