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Vol. 196, No. 3, 1998
Issue release date: 1998
Dermatology 1998;196:316–322
(DOI:10.1159/000017904)

Anti-Inflammatory Effect of Hamamelis Lotion in a UVB Erythema Test

Hughes-Formella B.J. · Bohnsack K. · Rippke F. · Benner G. · Rudolph M. · Tausch I. · Gassmueller J.
aBioSkin, Institute for Dermatological Research and Development, and bBeiersdorf AG, Hamburg, Germany

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Abstract

Background: Although Hamamelis virginiana has long been used in the traditional treatment of skin diseases, there are few controlled clinical studies defining the extent of its anti-inflammatory action. Objective:The anti-inflammatory efficacy of pH5 Eucerin aftersun lotion with 10% hamamelis distillate, the vehicle and a prior aftersun formulation were tested in 30 healthy volunteers using a modified UVB erythema test as model of inflammation. Methods: Four UVB doses ranging from 1 to 2 MED were evaluated in each subject. Test fields on the back were treated occlusively for 48 h following irradiation. Chromametry and visual scoring were used to determine the degree of erythema in the treated fields and an untreated, irradiated control field 7, 24 and 48 h after irradiation. Results: Erythema suppression ranged from approximately 20% at 7 h to 27% at 48 h in the hamamelis fields. A suppression of 11–15% was recorded in the fields treated with the other lotions. Significant differences were noted between hamamelis and these lotions. Conclusion: These data provide evidence for an anti-inflammatory action of the aftersun lotion with 10% hamamelis and support the usefulness of the UVB erythema test with multiple UV doses for the testing of nonsteroidal anti-inflammatory agents.



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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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References

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    External Resources

  6. Väänänen A, Hannuksela M: UVB erythema inhibited by topically applied substances. Acta Derm Venereol (Stockh) 1989;69:12–17.

    External Resources

  7. Juhlin J, Shroot B: Effect of drugs on the early and late phase UV erythema. Acta Dermatol Venereol (Stockh) 1992;72:222–223.
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    External Resources

  10. COLIPA sun protection factor test method, ref. 94/289 – October 1994. Bruxelles, European Cosmetic, Toiletry and Perfumery Association – COLIPA, 1994.
  11. Queille-Roussel C, Duteil L, Czernielewski J, Schaeffer H: Colorimetric evaluation of the human skin blanching assay; in Frosch PJ, Kligman AM (eds): Noninvasive Methods for the Quantification of Skin Functions. Berlin, Springer, 1993, pp 92–103.
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