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Background: The pathogenesis of androgenic alopecia is not fully understood. A microbial-driven inflammatory reaction abutting on the hair follicles might participate in the hair status anomaly. Objective: The aim of our study was to determine if ketoconazole (KCZ) which is active against the scalp microflora and shows some intrinsic anti-inflammatory activity might improve alopecia. Method: The effect of 2% KCZ shampoo was compared to that of an unmedicated shampoo used in combination with or without 2% minoxidil therapy. Results: Hair density and size and proportion of anagen follicles were improved almost similarly by both KCZ and minoxidil regimens. The sebum casual level appeared to be decreased by KCZ. Conclusion: Comparative data suggest that there may be a significant action of KCZ upon the course of androgenic alopecia and that Malassezia spp. may play a role in the inflammatory reaction. The clinical significance of the results awaits further controlled study in a larger group of subjects.
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- Jaworsky C, Kligman AM, Murphy GF: Characterization of inflammatory infiltrates in male pattern alopecia: Implications for pathogenesis. Br J Dermatol 1992;127:239–246.
- Piérard GE, Piérard-Franchimont C, Nikkels-Tassoudji N, Nikkels AF, Saint-Léger D: Improvement in the inflammatory aspect of androgenetic alopecia: A pilot study with an antimicrobial lotion. J Dermatol Treat 1996;7: 153–157.
- Hoffmann R, Happle R: Does interleukin-1 induce hair loss? Dermatology 1995;191: 273–275.
- Ford GP, Farr PM, Ive FA, Shuster S: The response of seborrhoeic dermatitis to ketoconazole. Br J Dermatol 1984;111:603–607.
- Skinner RB, Noah PW, Taylor RM, Zanolli MD, West S, Guin JD, Rosenberg EW: Double-blind treatment of seborrheic dermatitis with 2% ketoconazole cream. J Am Acad Dermatol 1985;12:852–856.
- Piérard GE, Piérard-Franchimont C, Van Cutsem J, Rurangirwa A, Hoppenbrouwers ML, Schrooten P: Ketoconozole 2% emulsion in the treatment of seborrheic dermatitis. Int J Dermatol 1991;30:806–809.
- Beetens JR, Loots W, Somers Y, Coene MC, De Clerck F: Ketoconazole inhibits the biosynthesis of leukotrienes in vitro and in vivo. Biochem Pharmacol 1986;35:883–891.
- Van Cutsem J, Van Gerven F, Cauwenbergh G, Odds F, Janssen PAJ: The antiinflammatory effects of ketoconazole. J Am Acad Dermatol 1991;25:257–261.
- Yoshimura T, Kudoh K, Aiba S, Tagami H: Anti-inflammatory effects of topical ketoconazole for the inflammation induced on the skin of hairless guinea-pigs by repeated applications of heat-killed spores of Malassezia furfur: A comparative study with hydrocortisone 17-butyrate. J Dermatol Treat 1995;6:113–116.
- Saint-Léger D, Kligman AM, Stoudemayer TJ: The role of the resident microflora in the pathogenesis of dandruff. J Soc Cosmet Chem 1989; 40:109–117.
- Piérard-Franchimont C, Arrese JE, Piérard GE: Immunohistochemical aspects of the link between Malassezia ovalis and seborrheic dermatitis. J Eur Acad Dermatol Venereol 1995;4: 14–19.
- Hamilton JB; Patterned loss of hair in man: Types and incidence. Ann NY Acad Sci 1951; 53:708–728.
- Norwood OT: Male pattern baldness: Classification and incidence. South Med J 1975;68: 1359–1365.
- Piérard-Franchimont C, Piérard GE: Approche physiopathologique de la séborrhée du cuir chevelu. Ann Dermatol Vénéréol 1988;115: 451–453.
- Rushton DH, Ramsay ID, Norris MJ, Gilkes JJH: Natural progression of male pattern baldness in young men. Clin Exp Dermatol 1991; 16:188–192.
- Brown M, Evans TW, Poyner T, Tooley PJH: The role of ketoconazole 2% shampoo in the treatment and prophylactic management of dandruff. J Dermatol Treat 1990;1:177–179.
- Dobrev H, Zissova L: Effect of ketoconazole 2% shampoo on scalp sebum level in patients with seborrhoeic dermatitis. Acta Derm Venereol 1997;77:132–134.