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Vol. 199, No. 4, 1999
Issue release date: 1999
Dermatology 1999;199:319–322
(DOI:10.1159/000018282)

Efficacy of Topical Application of Eosin Compared with Zinc Oxide Paste and Corticosteroid Cream for Diaper Dermatitis

Arad A. · Mimouni D. · Ben-Amitai D. · Zeharia A. · Mimouni M.
aSchneider Children’s Medical Center of Israel and bRabin Medical Center, Petah Tiqva, and cSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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Abstract

Background: Corticosteroids, zinc paste and eosin 2% are well-known topical agents for the treatment of moderate to severe diaper dermatitis. Among these treatments, the aqueous solution of eosin 2% is extensively used in several European countries, but not in the USA or Israel. Objective: To assess the therapeutic efficacy of eosin 2% solution compared to the other treatment modalities for diaper dermatitis. Methods: Fifty-four infants with diaper dermatitis, recruited from hospital wards and community clinics, were randomly assigned to three treatment groups: zinc oxide paste (containing allantoin 0.5%, cod liver oil 17% and zinc oxide 47epercnt;); clobetasone butyrate 0.05%, and aqueous solution of eosin 2%. The severity of the disorder was graded on a 6-point scale by observation and quantitative measurement of the lesions. The groups were compared for rates and time to heal. Due to the red color of eosin, a double-blind controlled study was impossible. Results: Following 5 days of treatment, the rate of complete healing in the group treated with eosin (61%) was significantly higher (p = 0.0479) than that in the zinc oxide paste and corticosteroid groups (22 and 33%, respectively). Furthermore, in cases of partial healing, the degree of improvement was higher in the eosin group than the other two (p = 0.0205). The fastest improvement was observed in the group treated with corticosteroid cream. Conclusion: Considering the potential hazards of topical corticosteroids and the greater overall efficacy of eosin 2% solution, we suggest that eosin is the preferred treatment for diaper dermatitis.

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References

  1. Janniger CK, Thomas I: Diaper dermatitis: An approach to prevention employing effective diaper care. Cutis 1993;52:153–155.
  2. Weiss M, Aronoff SC: Candida; in Behrman RE, Kliegman RM, Nelson WE (eds): Nelson Textbook of Pediatrics. Philadelphia, Saunders, 1996, pp 940–941.
  3. Jordan WE, Lawson KD, Berg RW, Franxman JJ, Marrer AM: Diaper dermatitis: Frequency and severity among a general infant population. Pediatr Dermatol 1986;3:198–207.

    External Resources

  4. Eosine Gifrer. Dictionnaire Vidal, ed 63. Paris, 1987, p 539.
  5. Shohat M. Mimouni M, Varsano I: Efficacy of topical application of glucocorticosteroids compared with eosin in infants with seborrheic dermatitis. Cutis 1987;40:67–68.

    External Resources

  6. Davis JA, Leyden JJ, Grove GL, Raynor WJ: Comparison of disposable diapers with fluff absorbent and fluff plus absorbent polymers: Effects on skin hydration, skin pH, and diaper dermatitis. Pediatr Dermatol 1989;6:102–108.

    External Resources

  7. Hurwitz S: Clinical Pediatric Dermatology. Philadelphia, Saunders, 1993, pp 34–38.
  8. Wong DL, Brantly D, Clutter LB, De Simone D, Lammert D, Nix K, Perry KA, Smith DP, White KH: Diapering choices: A critical review of the issues. Pediatr Nurs 1992;18:41–54.
  9. Ortega E, Burdick KH, Segre EJ: Adrenal suppression by clobetasol propionate (letter). Lancet 1975;i:1200.
  10. Weston WL, Sams WM Jr, Morris HG, Arthur JM, Blakeman GJ, Andresen M: Morning plasma cortisol levels in infants treated with topical fluorinated glucocorticosteroids. Pediatrics 1980;65:103–106.

    External Resources

  11. Feiwel M, James VH, Barnett ES: Effect of potent topical steroids on plasma-cortisol levels of infants and children with eczema. Lancet 1969;i:485–487.
  12. Shohat M, Mimouni M, Shuper A, Varsano I: Adrenocortical suppression by topical application of glucocorticosteroids in infants with seborrheic dermatitis. Clin Pediatr (Phila) 1986; 25:209–212.

    External Resources

  13. Federal Register: Rules and Regulations. D&C Ped 1982;47:230.


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