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Vol. 199, No. 4, 1999
Issue release date: 1999
Section title: Pharmacology and Treatment
Dermatology 1999;199:319–322
(DOI:10.1159/000018282)

Efficacy of Topical Application of Eosin Compared with Zinc Oxide Paste and Corticosteroid Cream for Diaper Dermatitis

Arad A. · Mimouni D. · Ben-Amitai D. · Zeharia A. · Mimouni M.
aSchneider Children’s Medical Center of Israel and bRabin Medical Center, Petah Tiqva, and cSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Published online: 12/24/1999

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: Corticosteroids, zinc paste and eosin 2% are well-known topical agents for the treatment of moderate to severe diaper dermatitis. Among these treatments, the aqueous solution of eosin 2% is extensively used in several European countries, but not in the USA or Israel. Objective: To assess the therapeutic efficacy of eosin 2% solution compared to the other treatment modalities for diaper dermatitis. Methods: Fifty-four infants with diaper dermatitis, recruited from hospital wards and community clinics, were randomly assigned to three treatment groups: zinc oxide paste (containing allantoin 0.5%, cod liver oil 17% and zinc oxide 47epercnt;); clobetasone butyrate 0.05%, and aqueous solution of eosin 2%. The severity of the disorder was graded on a 6-point scale by observation and quantitative measurement of the lesions. The groups were compared for rates and time to heal. Due to the red color of eosin, a double-blind controlled study was impossible. Results: Following 5 days of treatment, the rate of complete healing in the group treated with eosin (61%) was significantly higher (p = 0.0479) than that in the zinc oxide paste and corticosteroid groups (22 and 33%, respectively). Furthermore, in cases of partial healing, the degree of improvement was higher in the eosin group than the other two (p = 0.0205). The fastest improvement was observed in the group treated with corticosteroid cream. Conclusion: Considering the potential hazards of topical corticosteroids and the greater overall efficacy of eosin 2% solution, we suggest that eosin is the preferred treatment for diaper dermatitis.


Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Published online: 12/24/1999

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Janniger CK, Thomas I: Diaper dermatitis: An approach to prevention employing effective diaper care. Cutis 1993;52:153–155.
  2. Weiss M, Aronoff SC: Candida; in Behrman RE, Kliegman RM, Nelson WE (eds): Nelson Textbook of Pediatrics. Philadelphia, Saunders, 1996, pp 940–941.
  3. Jordan WE, Lawson KD, Berg RW, Franxman JJ, Marrer AM: Diaper dermatitis: Frequency and severity among a general infant population. Pediatr Dermatol 1986;3:198–207.

    External Resources

  4. Eosine Gifrer. Dictionnaire Vidal, ed 63. Paris, 1987, p 539.
  5. Shohat M. Mimouni M, Varsano I: Efficacy of topical application of glucocorticosteroids compared with eosin in infants with seborrheic dermatitis. Cutis 1987;40:67–68.

    External Resources

  6. Davis JA, Leyden JJ, Grove GL, Raynor WJ: Comparison of disposable diapers with fluff absorbent and fluff plus absorbent polymers: Effects on skin hydration, skin pH, and diaper dermatitis. Pediatr Dermatol 1989;6:102–108.

    External Resources

  7. Hurwitz S: Clinical Pediatric Dermatology. Philadelphia, Saunders, 1993, pp 34–38.
  8. Wong DL, Brantly D, Clutter LB, De Simone D, Lammert D, Nix K, Perry KA, Smith DP, White KH: Diapering choices: A critical review of the issues. Pediatr Nurs 1992;18:41–54.
  9. Ortega E, Burdick KH, Segre EJ: Adrenal suppression by clobetasol propionate (letter). Lancet 1975;i:1200.
  10. Weston WL, Sams WM Jr, Morris HG, Arthur JM, Blakeman GJ, Andresen M: Morning plasma cortisol levels in infants treated with topical fluorinated glucocorticosteroids. Pediatrics 1980;65:103–106.

    External Resources

  11. Feiwel M, James VH, Barnett ES: Effect of potent topical steroids on plasma-cortisol levels of infants and children with eczema. Lancet 1969;i:485–487.
  12. Shohat M, Mimouni M, Shuper A, Varsano I: Adrenocortical suppression by topical application of glucocorticosteroids in infants with seborrheic dermatitis. Clin Pediatr (Phila) 1986; 25:209–212.

    External Resources

  13. Federal Register: Rules and Regulations. D&C Ped 1982;47:230.