Go is the most abundant G protein in the central nervous system, where it comprises about 1% of membrane protein in mammalian brains. It functions to couple cell surface receptors to intercellular effectors, which is a critical process for cells to receive, interpret and respond to extracellular signals. Go protein belongs to the pertussis toxin-sensitive Gi/Go subfamily of G proteins. A number of G-protein-coupled receptors transmit stimuli to intercellular effectors through Go. Go regulates several cellular effectors, including ion channels, enzymes, and even small GTPases to modulate cellular function. This review summarizes some of the advances in Go research and proposes areas to be further addressed in exploring the functional role of Go.
© 2009 S. Karger AG, Basel
- G protein
- G-protein-coupled receptors
- Signal transduction
- Central nervous system
- Alzheimer’s disease
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Dr. Meisheng Jiang
Department of Molecular and Medical Pharmacology
David Geffen School of Medicine, University of California Los Angeles
710 Westwood Plaza, Reed 3127, Los Angeles, CA 90095 (USA)
Tel. +1 310 794 7802, Fax +1 310 794 7380, E-Mail firstname.lastname@example.org
Received: March 14, 2008
Accepted after revision: April 9, 2008
Published online: February 12, 2009
Number of Print Pages : 19
Number of Figures : 3, Number of Tables : 0, Number of References : 185
Vol. 17, No. 1, Year 2009 (Cover Date: February 2009)
Journal Editor: Ip N.Y. (Hong Kong)
ISSN: 1424-862X (Print), eISSN: 1424-8638 (Online)
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