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Vol. 17, No. 1, 2009
Issue release date: February 2009
Free Access
Neurosignals 2009;17:23–41
(DOI:10.1159/000186688)

Molecular Mechanisms of Go Signaling

Jiang M. · Bajpayee N.S.
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Calif., USA
email Corresponding Author

Abstract

Go is the most abundant G protein in the central nervous system, where it comprises about 1% of membrane protein in mammalian brains. It functions to couple cell surface receptors to intercellular effectors, which is a critical process for cells to receive, interpret and respond to extracellular signals. Go protein belongs to the pertussis toxin-sensitive Gi/Go subfamily of G proteins. A number of G-protein-coupled receptors transmit stimuli to intercellular effectors through Go. Go regulates several cellular effectors, including ion channels, enzymes, and even small GTPases to modulate cellular function. This review summarizes some of the advances in Go research and proposes areas to be further addressed in exploring the functional role of Go.


 goto top of outline Key Words

  • G protein
  • Go
  • G-protein-coupled receptors
  • Signal transduction
  • Effectors
  • Central nervous system
  • Alzheimer’s disease

 goto top of outline Abstract

Go is the most abundant G protein in the central nervous system, where it comprises about 1% of membrane protein in mammalian brains. It functions to couple cell surface receptors to intercellular effectors, which is a critical process for cells to receive, interpret and respond to extracellular signals. Go protein belongs to the pertussis toxin-sensitive Gi/Go subfamily of G proteins. A number of G-protein-coupled receptors transmit stimuli to intercellular effectors through Go. Go regulates several cellular effectors, including ion channels, enzymes, and even small GTPases to modulate cellular function. This review summarizes some of the advances in Go research and proposes areas to be further addressed in exploring the functional role of Go.

Copyright © 2009 S. Karger AG, Basel


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 goto top of outline Author Contacts

Dr. Meisheng Jiang
Department of Molecular and Medical Pharmacology
David Geffen School of Medicine, University of California Los Angeles
710 Westwood Plaza, Reed 3127, Los Angeles, CA 90095 (USA)
Tel. +1 310 794 7802, Fax +1 310 794 7380, E-Mail jm@ucla.edu


 goto top of outline Article Information

Received: March 14, 2008
Accepted after revision: April 9, 2008
Published online: February 12, 2009
Number of Print Pages : 19
Number of Figures : 3, Number of Tables : 0, Number of References : 185


 goto top of outline Publication Details

Neurosignals

Vol. 17, No. 1, Year 2009 (Cover Date: February 2009)

Journal Editor: Ip N.Y. (Hong Kong)
ISSN: 1424-862X (Print), eISSN: 1424-8638 (Online)

For additional information: http://www.karger.com/NSG


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Abstract

Go is the most abundant G protein in the central nervous system, where it comprises about 1% of membrane protein in mammalian brains. It functions to couple cell surface receptors to intercellular effectors, which is a critical process for cells to receive, interpret and respond to extracellular signals. Go protein belongs to the pertussis toxin-sensitive Gi/Go subfamily of G proteins. A number of G-protein-coupled receptors transmit stimuli to intercellular effectors through Go. Go regulates several cellular effectors, including ion channels, enzymes, and even small GTPases to modulate cellular function. This review summarizes some of the advances in Go research and proposes areas to be further addressed in exploring the functional role of Go.



 goto top of outline Author Contacts

Dr. Meisheng Jiang
Department of Molecular and Medical Pharmacology
David Geffen School of Medicine, University of California Los Angeles
710 Westwood Plaza, Reed 3127, Los Angeles, CA 90095 (USA)
Tel. +1 310 794 7802, Fax +1 310 794 7380, E-Mail jm@ucla.edu


 goto top of outline Article Information

Received: March 14, 2008
Accepted after revision: April 9, 2008
Published online: February 12, 2009
Number of Print Pages : 19
Number of Figures : 3, Number of Tables : 0, Number of References : 185


 goto top of outline Publication Details

Neurosignals

Vol. 17, No. 1, Year 2009 (Cover Date: February 2009)

Journal Editor: Ip N.Y. (Hong Kong)
ISSN: 1424-862X (Print), eISSN: 1424-8638 (Online)

For additional information: http://www.karger.com/NSG


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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