Gq family members of heterotrimeric G protein activate β isoforms of phospholipase C that hydrolyzes phosphatidylinositol phosphate to diacylglycerol and inositol trisphosphate, leading to the protein kinase C activation and intracellular Ca2+ mobilization, respectively. To understand the functions and regulatory mechanisms of Gq-signaling pathways, we first introduce the Gαq-interacting proteins, which function as the effectors and the modulators of Gq. Next, we describe the Pasteurella multocida toxin and YM-254890, which are useful tools to investigate Gq signaling as activator and inhibitor, respectively. Finally, we discuss the physiological function of Gq in developmental brain, especially in neural progenitor cells.
© 2009 S. Karger AG, Basel
- Phospholipase Cβ
- Interacting proteins
- Pasteurella multocida toxin
- Neural progenitor cells
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Dr. H. Itoh
Department of Cell Biology, Graduate School of Biological Sciences
Nara Institute of Science and Technology
Takayama, Ikoma, Nara (Japan)
Tel. +81 743 72 5440, Fax +81 743 72 5449, E-Mail firstname.lastname@example.org
Received: June 14, 2008
Accepted after revision: August 13, 2008
Published online: February 12, 2009
Number of Print Pages : 13
Number of Figures : 2, Number of Tables : 1, Number of References : 129
Vol. 17, No. 1, Year 2009 (Cover Date: February 2009)
Journal Editor: Ip N.Y. (Hong Kong)
ISSN: 1424-862X (Print), eISSN: 1424-8638 (Online)
For additional information: http://www.karger.com/NSG
Copyright / Drug Dosage / Disclaimer
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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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